TMPRSS6

TMPRSS6
Identifiers
Aliases	TMPRSS6, IRIDA, transmembrane protease, serine 6, matriptase-2, transmembrane serine protease 6
External IDs	MGI: 1919003 HomoloGene: 12408 GeneCards: TMPRSS6
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	37,109,563 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	78,468,634 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• serine-type peptidase activity; • peptidase activity; • protein binding; • hydrolase activity; • serine-type endopeptidase activity; • metalloendopeptidase activity;
Cellular component	• membrane; • integral component of membrane; • intracellular; • extracellular space; • plasma membrane;
Biological process	• membrane protein proteolysis; • intracellular signal transduction; • angiogenesis; • fibrinolysis; • negative regulation of BMP signaling pathway; • self proteolysis; • extracellular matrix organization; • negative regulation of transcription, DNA-templated; • proteolysis; • cellular iron ion homeostasis; • iron ion homeostasis; • negative regulation of transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter; • extracellular matrix disassembly; • collagen catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	164656
	71753
	ENSG00000187045
	ENSMUSG00000016942
	Q8IU80
	Q9DBI0
	NM_001289000; NM_001289001; NM_153609
	NM_027902; NM_001355601
	NP_001275929; NP_001275930; NP_705837
	NP_082178; NP_001342530
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protease, serine 6 (also known as matriptase-2) is an enzyme that in humans is encoded by the TMPRSS6 gene.^[5]

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187045 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016942 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: TMPRSS6 transmembrane protease, serine 6".

Netzel-Arnett S, Hooper JD, Szabo R, et al. (2004). "Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer". Cancer Metastasis Rev. 22 (2–3): 237–58. doi:10.1023/A:1023003616848. PMID 12784999.
Ramsay AJ, Reid JC, Velasco G, et al. (2007). "The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles". Front. Biosci. 13 (13): 569–79. doi:10.2741/2702. PMID 17981570.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Velasco G, Cal S, Quesada V, et al. (2002). "Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins". J. Biol. Chem. 277 (40): 37637–46. doi:10.1074/jbc.M203007200. PMID 12149247.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hartikainen JM, Tuhkanen H, Kataja V, et al. (2006). "Refinement of the 22q12-q13 breast cancer--associated region: evidence of TMPRSS6 as a candidate gene in an eastern Finnish population". Clin. Cancer Res. 12 (5): 1454–62. doi:10.1158/1078-0432.CCR-05-1417. PMID 16533768.
Parr C, Sanders AJ, Davies G, et al. (2007). "Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients". Clin. Cancer Res. 13 (12): 3568–76. doi:10.1158/1078-0432.CCR-06-2357. PMID 17575220.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187045 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016942 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] 1 2 "Entrez Gene: TMPRSS6 transmembrane protease, serine 6".

TMPRSS6

References

Further reading