TMEM59

TMEM59
Identifiers
Aliases	TMEM59, C1orf8, HSPC001, DCF1, PRO195, UNQ169, transmembrane protein 59
External IDs	MGI: 1929278 HomoloGene: 3583 GeneCards: TMEM59
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	54,053,504 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	107,200,996 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• endopeptidase activity; • protein binding;
Cellular component	• integral component of membrane; • endosome; • late endosome; • Golgi apparatus; • late endosome membrane; • Golgi medial cisterna; • membrane; • Golgi membrane; • plasma membrane; • Golgi cis cisterna; • lysosomal membrane; • Golgi trans cisterna; • lysosome; • extracellular exosome;
Biological process	• positive regulation of autophagy; • proteolysis; • autophagy; • negative regulation of protein glycosylation in Golgi; • negative regulation of protein processing; • negative regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	9528
	56374
	ENSG00000116209
	ENSMUSG00000028618
	Q9BXS4
	Q9QY73
NM_001305043; NM_001305049; NM_001305050; NM_001305051; NM_001305052;
	NM_001305066; NM_004872
	NM_029565
NP_001291972; NP_001291978; NP_001291979; NP_001291980; NP_001291981;
	NP_001291995; NP_004863
	NP_083841
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene.^[5]^[6]

TMEM59 is a membrane bound protein that is localized to the Golgi apparatus.^[7] The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi glycosylation of amyloid precursor protein (APP) and blocks APP cleavage by the α- and β-amyloid precursor protein secretases and therefore inhibits formation of the beta amyloid peptide that forms amyloid plaques in Alzheimer's disease.^[7]Moreover, TMEM59 has been shown to potentiate wnt siganling by promoting formation of the wnt receptor signalosomes. Transmembrane interactions between TMEM59 and the wnt receptor Frizzled were found to drive receptor multimerization that leads to improved potency and efficiacy of wnt signaling.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116209 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028618 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
↑ "Entrez Gene: TMEM59 transmembrane protein 59".
1 2 Ullrich S, Münch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (July 2010). "The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein". The Journal of Biological Chemistry. 285 (27): 20664–74. doi:10.1074/jbc.M109.055608. PMC 2898310. PMID 20427278.
↑ Gerlach JP, Jordens I, Tauriello DV, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJ, Egan DA, Maurice MM (April 2018). "TMEM59 potentiates Wnt signaling by promoting signalosome formation". Proceedings of the National Academy of Sciences of the United States of America. 115 (17): E3996–E4005. doi:10.1073/pnas.1721321115. PMC 5924918. PMID 29632210.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116209 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028618 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9653160-5] Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.

[entrez-6] "Entrez Gene: TMEM59 transmembrane protein 59".

[Ullrich_2010-7] 1 2 Ullrich S, Münch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (July 2010). "The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein". The Journal of Biological Chemistry. 285 (27): 20664–74. doi:10.1074/jbc.M109.055608. PMC 2898310. PMID 20427278.

[8] Gerlach JP, Jordens I, Tauriello DV, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJ, Egan DA, Maurice MM (April 2018). "TMEM59 potentiates Wnt signaling by promoting signalosome formation". Proceedings of the National Academy of Sciences of the United States of America. 115 (17): E3996–E4005. doi:10.1073/pnas.1721321115. PMC 5924918. PMID 29632210.

TMEM59

References

Further reading