TMED2

TMED2
Identifiers
Aliases	TMED2, P24A, RNP24, p24, p24b1, p24beta1, transmembrane p24 trafficking protein 2
External IDs	MGI: 3704329 HomoloGene: 55991 GeneCards: TMED2
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	123,598,577 bp[1]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• protein binding;
Cellular component	• transport vesicle; • integral component of membrane; • ER to Golgi transport vesicle membrane; • Golgi apparatus; • Golgi membrane; • intracellular membrane-bounded organelle; • Golgi cisterna membrane; • zymogen granule membrane; • membrane; • endoplasmic reticulum; • endoplasmic reticulum membrane; • cytoplasmic vesicle membrane; • cytoplasmic vesicle; • COPI-coated vesicle; • endoplasmic reticulum-Golgi intermediate compartment membrane; • endoplasmic reticulum-Golgi intermediate compartment; • COPI-coated vesicle membrane; • COPII-coated ER to Golgi transport vesicle;
Biological process	• cargo loading into vesicle; • neural tube closure; • maternal placenta development; • embryonic placenta development; • COPII vesicle coating; • ER to Golgi vesicle-mediated transport; • heart looping; • positive regulation of gene expression; • somitogenesis; • Golgi organization; • post-anal tail morphogenesis; • embryonic morphogenesis; • multicellular organism growth; • in utero embryonic development; • protein transport; • negative regulation of GTPase activity; • COPI coating of Golgi vesicle; • labyrinthine layer blood vessel development; • vesicle-mediated transport; • somite rostral/caudal axis specification; • intracellular protein transport; • retrograde vesicle-mediated transport, Golgi to ER; • protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	10959
	100862175
	ENSG00000086598
	n/a
	Q15363
	Q9R0Q3
	NM_006815; NM_001321445
	XM_003945446
	NP_001308374; NP_006806
	NP_062744
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane emp24 domain-containing protein 2 is a protein that in humans is encoded by the TMED2 gene.^[4]^[5]

Interactions

TMED2 has been shown to interact with GORASP1^[6] and GORASP2.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000086598 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (September 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". J Biol Chem. 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.
↑ "Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2".
1 2 Barr, F A; Preisinger C; Kopajtich R; Körner R (Dec 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. United States. 155 (6): 885–91. doi:10.1083/jcb.200108102. ISSN 0021-9525. PMC 2150891. PMID 11739402.

Fiedler K, Veit M, Stamnes MA, Rothman JE (1996). "Bimodal interaction of coatomer with the p24 family of putative cargo receptors". Science. 273 (5280): 1396–9. Bibcode:1996Sci...273.1396F. doi:10.1126/science.273.5280.1396. PMID 8703076.
Gommel D, Orci L, Emig EM, et al. (1999). "p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway". FEBS Lett. 447 (2–3): 179–85. doi:10.1016/S0014-5793(99)00246-X. PMID 10214941.
Majoul I, Straub M, Hell SW, et al. (2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Dev. Cell. 1 (1): 139–53. doi:10.1016/S1534-5807(01)00004-1. PMID 11703931.
Barr FA, Preisinger C, Kopajtich R, Körner R (2002). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chen F, Hasegawa H, Schmitt-Ulms G, et al. (2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature. 440 (7088): 1208–12. Bibcode:2006Natur.440.1208C. doi:10.1038/nature04667. PMID 16641999.
Luo W, Wang Y, Reiser G (2007). "p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking". J. Biol. Chem. 282 (41): 30246–55. doi:10.1074/jbc.M703205200. PMID 17693410.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000086598 - Ensembl, May 2017

[2] "Human PubMed Reference:".

[3] "Mouse PubMed Reference:".

[pmid8663407-4] Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (September 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". J Biol Chem. 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.

[entrez-5] "Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2".

[pmid11739402-6] 1 2 Barr, F A; Preisinger C; Kopajtich R; Körner R (Dec 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. United States. 155 (6): 885–91. doi:10.1083/jcb.200108102. ISSN 0021-9525. PMC 2150891. PMID 11739402.

TMED2

Interactions

References

Further reading