TMBIM4

TMBIM4
Identifiers
AliasesTMBIM4, GAAP, LFG4, S1R, ZPRO, CGI-119, transmembrane BAX inhibitor motif containing 4
External IDsMGI: 1915462 HomoloGene: 56740 GeneCards: TMBIM4
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q14.3Start66,135,846 bp[1]
End66,170,072 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51643

68212

Ensembl

ENSG00000155957

ENSMUSG00000020225

UniProt

Q9HC24

Q9DA39

RefSeq (mRNA)

NM_016056
NM_001282606
NM_001282609
NM_001282610

NM_026617

RefSeq (protein)

NP_001269535
NP_001269538
NP_001269539
NP_057140
NP_001269535.1

NP_080893

Location (UCSC)Chr 12: 66.14 – 66.17 MbChr 10: 120.2 – 120.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane BAX inhibitor motif-containing protein 4 is a protein that in humans is encoded by the TMBIM4 gene.[5][6][7] It is also known as human Golgi anti-apoptotic protein (hGAAP) due to its function and sub-cellular localization.

Function

Human GAAP is a protein present in the Golgi that helps regulate apoptosis, a form of programmed cell death. By regulating the fluxes of Ca+2, an increase of GAAP can help prevent apoptosis.[8][9] GAAP is also involved in promoting cell migration[10] and has been identified as a novel Golgi cation channel.[11] Other GAAPs can be foun in all eucaryotes analyzed and in some bacteria. A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox.

See also

  • Golgi
  • Apoptosis
  • Ion channel

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000155957 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020225 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  7. ↑ "Entrez Gene: TMBIM4 transmembrane BAX inhibitor motif containing 4".
  8. ↑ de Mattia F, Gubser C, van Dommelen MM, Visch HJ, Distelmaier F, Postigo A, Luyten T, Parys JB, de Smedt H, Smith GL, Willems PH, van Kuppeveld FJ (August 2009). "Human Golgi antiapoptotic protein modulates intracellular calcium fluxes". Molecular Biology of the Cell. 20 (16): 3638–45. doi:10.1091/mbc.E09-05-0385. PMC 2777924. PMID 19553469.
  9. ↑ Saraiva N, Prole DL, Carrara G, Maluquer de Motes C, Johnson BF, Byrne B, Taylor CW, Smith GL (May 2013). "Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium". The Journal of Biological Chemistry. 288 (18): 13057–67. doi:10.1074/jbc.M112.414367. PMC 3642348. PMID 23508950.
  10. ↑ Saraiva, Nuno; Prole, David L.; Carrara, Guia; Johnson, Benjamin F.; Taylor, Colin W.; Parsons, Maddy; Smith, Geoffrey L. (2013-08-19). "hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2". J Cell Biol. 202 (4): 699–713. doi:10.1083/jcb.201301016. ISSN 0021-9525. PMC 3747308. PMID 23940116.
  11. ↑ Carrara, Guia; Saraiva, Nuno; Parsons, Maddy; Byrne, Bernadette; Prole, David L.; Taylor, Colin W.; Smith, Geoffrey L. (2015-05-01). "Golgi Anti-apoptotic Proteins Are Highly Conserved Ion Channels That Affect Apoptosis and Cell Migration". Journal of Biological Chemistry. 290 (18): 11785–11801. doi:10.1074/jbc.M115.637306. ISSN 0021-9258. PMC 4416878. PMID 25713081.

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (August 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Gubser C, Bergamaschi D, Hollinshead M, Lu X, van Kuppeveld FJ, Smith GL (February 2007). "A new inhibitor of apoptosis from vaccinia virus and eukaryotes". PLoS Pathogens. 3 (2): e17. doi:10.1371/journal.ppat.0030017. PMC 1803007. PMID 17319741.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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