TLX2

TLX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A03
Identifiers
Aliases	TLX2, HOX11L1, NCX, T-cell leukemia homeobox 2, T cell leukemia homeobox 2
External IDs	MGI: 1350935 HomoloGene: 7575 GeneCards: TLX2
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	74,517,147 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	83,070,293 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; • sequence-specific DNA binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding;
Cellular component	• cytoplasm; • cell nucleus; • cellular component;
Biological process	• multicellular organism development; • enteric nervous system development; • mesoderm formation; • regulation of transcription, DNA-templated; • negative regulation of dendrite morphogenesis; • transcription, DNA-templated; • transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	3196
	21909
	ENSG00000115297
	ENSMUSG00000068327
	O43763
	Q61663
	NM_016170
	NM_009392
	NP_057254
	NP_033418
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene.^[5]^[6]

Interactions

TLX2 has been shown to interact with YWHAH.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115297 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068327 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I (Jun 1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1". Cytogenet Cell Genet. 84 (1–2): 115–7. doi:10.1159/000015234. PMID 10343123.
↑ "Entrez Gene: TLX2 T-cell leukemia homeobox 2".
↑ Tang, S J; Suen T C; McInnes R R; Buchwald M (Sep 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". J. Biol. Chem. UNITED STATES. 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. ISSN 0021-9258. PMID 9738002.

Kaifi JT, Wagner M, Schurr PG, et al. (2007). "Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors". Oncol. Rep. 16 (4): 915–9. doi:10.3892/or.16.4.915. PMID 16969514.
Borghini S, Bachetti T, Fava M, et al. (2006). "The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells". Biochem. J. 395 (2): 355–61. doi:10.1042/BJ20051386. PMC 1422762. PMID 16402914.
Parisi MA, Lipman NS, Clarke CM, et al. (2006). "Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction". J. Pediatr. Surg. 40 (11): 1760–5. doi:10.1016/j.jpedsurg.2005.07.010. PMID 16291166.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Iitsuka Y, Shimizu H, Kang MM, et al. (1999). "An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells". J. Biol. Chem. 274 (34): 24401–7. doi:10.1074/jbc.274.34.24401. PMID 10446220.
Tang SJ, Suen TC, McInnes RR, Buchwald M (1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". J. Biol. Chem. 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. PMID 9738002.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115297 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068327 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10343123-5] Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I (Jun 1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1". Cytogenet Cell Genet. 84 (1–2): 115–7. doi:10.1159/000015234. PMID 10343123.

[entrez-6] "Entrez Gene: TLX2 T-cell leukemia homeobox 2".

[pmid9738002-7] Tang, S J; Suen T C; McInnes R R; Buchwald M (Sep 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". J. Biol. Chem. UNITED STATES. 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. ISSN 0021-9258. PMID 9738002.

TLX2

Interactions

References

Further reading