TJP3

TJP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTJP3, ZO-3, ZO3, tight junction protein 3
External IDsMGI: 1351650 HomoloGene: 8458 GeneCards: TJP3
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start3,708,109 bp[1]
End3,750,813 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

27134

27375

Ensembl

ENSG00000105289

ENSMUSG00000034917

UniProt

O95049

Q9QXY1

RefSeq (mRNA)

NM_014428
NM_001267560
NM_001267561

NM_001282095
NM_001282096
NM_013769

RefSeq (protein)

NP_001254489
NP_001254490

n/a

Location (UCSC)Chr 19: 3.71 – 3.75 MbChr 10: 81.27 – 81.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tight junction protein ZO-3 is a protein that in humans is encoded by the TJP3 gene.[5]

Interactions

TJP3 has been shown to interact with tight junction protein 1.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105289 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034917 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: TJP3 tight junction protein 3 (zona occludens 3)".
  6. ↑ Wittchen, E S; Haskins J; Stevenson B R (Dec 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. UNITED STATES. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. ISSN 0021-9258. PMID 10575001.

Further reading

  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Roh MH, Liu CJ, Laurinec S, Margolis B (2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions". J. Biol. Chem. 277 (30): 27501–9. doi:10.1074/jbc.M201177200. PMID 12021270.
  • Kausalya PJ, Reichert M, Hunziker W (2001). "Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells". FEBS Lett. 505 (1): 92–6. doi:10.1016/S0014-5793(01)02786-7. PMID 11557048.
  • Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
  • Wittchen ES, Haskins J, Stevenson BR (2000). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. PMID 10575001.
  • Haskins J, Gu L, Wittchen ES, et al. (1998). "ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin". J. Cell Biol. 141 (1): 199–208. doi:10.1083/jcb.141.1.199. PMC 2132714. PMID 9531559.


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