TIP39

PTH2
Identifiers
AliasesPTH2, TIP39, parathyroid hormone 2
External IDsMGI: 2152297 HomoloGene: 14235 GeneCards: PTH2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.33Start49,422,414 bp[1]
End49,423,441 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

113091

114640

Ensembl

ENSG00000142538

ENSMUSG00000038300

UniProt

Q96A98

Q91W27

RefSeq (mRNA)

NM_178449

NM_053256

RefSeq (protein)

NP_848544

NP_444486

Location (UCSC)Chr 19: 49.42 – 49.42 MbChr 7: 45.18 – 45.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tuberoinfundibular peptide of 39 residues is a protein that in humans is encoded by the PTH2 gene.[5][6]

TIP39 is related to parathyroid hormone (PTH; MIM 168450) and PTH-related protein (PTHRP; MIM 168470) and is a ligand for PTH receptor-2 (PTHR2; MIM 601469) (John et al., 2002).[supplied by OMIM][6]

The molecular interaction of TIP39 with the PTH2 receptor has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000142538 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038300 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ John MR, Arai M, Rubin DA, Jonsson KB, Juppner H (Feb 2002). "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues". Endocrinology. 143 (3): 1047–57. doi:10.1210/en.143.3.1047. PMID 11861531.
  6. 1 2 "Entrez Gene: TIP39 tuberoinfundibular 39 residue protein precursor".
  7. ↑ Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D (2017). "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5". Biochemical Pharmacology. doi:10.1016/j.bcp.2016.12.013.

Further reading

  • Usdin TB, Hoare SR, Wang T, et al. (1999). "TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus". Nat. Neurosci. 2 (11): 941–3. doi:10.1038/14724. PMID 10526330.
  • Hoare SR, Clark JA, Usdin TB (2000). "Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity". J. Biol. Chem. 275 (35): 27274–83. doi:10.1074/jbc.M003910200. PMID 10854439.
  • Dobolyi A, Ueda H, Uchida H, et al. (2002). "Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1651–6. doi:10.1073/pnas.042416199. PMC 122245. PMID 11818570.
  • Hansen IA, Jakob O, Wortmann S, et al. (2002). "Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family". J. Endocrinol. 174 (1): 95–102. doi:10.1677/joe.0.1740095. PMID 12098667.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Della Penna K, Kinose F, Sun H, et al. (2003). "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor". Neuropharmacology. 44 (1): 141–53. doi:10.1016/S0028-3908(02)00335-0. PMID 12559132.
  • Misiano P, Scott BB, Scheideler MA, Garnier M (2004). "PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation". Eur. J. Pharmacol. 468 (3): 159–66. doi:10.1016/S0014-2999(03)01673-X. PMID 12754053.
  • Bisello A, Manen D, Pierroz DD, et al. (2004). "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization". Mol. Endocrinol. 18 (6): 1486–98. doi:10.1210/me.2003-0487. PMID 14988434.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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