TIMM9

TIMM9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BSK
Identifiers
Aliases	TIMM9, TIM9, TIM9A, translocase of inner mitochondrial membrane 9
External IDs	MGI: 1353436 HomoloGene: 40847 GeneCards: TIMM9
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	58,427,614 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	71,136,684 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• zinc ion binding; • chaperone binding; • protein binding; • protein homodimerization activity; • metal ion binding; • transporter activity; • protein transporter activity;
Cellular component	• mitochondrial inner membrane; • mitochondrial intermembrane space; • mitochondrial intermembrane space protein transporter complex; • membrane; • mitochondrion; • mitochondrial inner membrane protein insertion complex;
Biological process	• protein transport; • protein import into mitochondrial inner membrane; • protein targeting to mitochondrion; • chaperone-mediated protein transport; • sensory perception of sound;
	Sources:Amigo / QuickGO
Orthologs
	26520
	30056
	ENSG00000100575
	ENSMUSG00000021079
	Q9Y5J7
	Q9WV98
NM_001304485; NM_001304486; NM_001304487; NM_001304488; NM_001304489;
	NM_001304490; NM_001304491; NM_012460
	NM_001024853; NM_001024854; NM_001286203; NM_013896
NP_001291414; NP_001291415; NP_001291416; NP_001291417; NP_001291418;
	NP_001291419; NP_001291420; NP_036592
	NP_001020024; NP_001020025; NP_001273132; NP_038924
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim9 is an enzyme that in humans is encoded by the TIMM9 gene.^[5]^[6]^[7]

TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100575 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021079 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Feb 2000). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID 10552927.
↑ Muhlenbein N, Hofmann S, Rothbauer U, Bauer MF (Mar 2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J Biol Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
1 2 "Entrez Gene: TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)".

Webb CT, Gorman MA, Lazarou M, et al. (2006). "Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller". Mol. Cell. 21 (1): 123–33. doi:10.1016/j.molcel.2005.11.010. PMID 16387659.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vial S, Lu H, Allen S, et al. (2002). "Assembly of Tim9 and Tim10 into a functional chaperone". J. Biol. Chem. 277 (39): 36100–8. doi:10.1074/jbc.M202310200. PMID 12138093.
Rothbauer U, Hofmann S, Mühlenbein N, et al. (2001). "Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria". J. Biol. Chem. 276 (40): 37327–34. doi:10.1074/jbc.M105313200. PMID 11489896.
Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Lett. 464 (1–2): 41–7. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100575 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021079 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10552927-5] Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Feb 2000). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID 10552927.

[pmid14726512-6] Muhlenbein N, Hofmann S, Rothbauer U, Bauer MF (Mar 2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J Biol Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.

[entrez-7] 1 2 "Entrez Gene: TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)".

TIMM9

References

Further reading