TICAM2

TICAM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M1W
Identifiers
Aliases	TICAM2, MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM, toll like receptor adaptor molecule 2
External IDs	OMIM: 608321 MGI: 3040056 HomoloGene: 11014 GeneCards: TICAM2
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	115,602,479 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	46,574,533 bp[2]
Gene ontology
Molecular function	• signal transducer activity; • protein binding;
Cellular component	• cytoplasm; • endosome; • late endosome; • Golgi apparatus; • early endosome membrane; • membrane; • late endosome membrane; • plasma membrane; • early endosome; • endoplasmic reticulum; • endosome membrane; • secretory granule membrane;
Biological process	• toll-like receptor 4 signaling pathway; • negative regulation of chemokine (C-C motif) ligand 5 production; • immune system process; • TRAM-dependent toll-like receptor 4 signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • positive regulation of toll-like receptor 4 signaling pathway; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • inflammatory response; • cellular response to lipopolysaccharide; • I-kappaB kinase/NF-kappaB signaling; • negative regulation of toll-like receptor 4 signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • signal transduction; • necroptotic process; • apoptotic signaling pathway; • negative regulation of MyD88-independent toll-like receptor signaling pathway; • innate immune response; • neutrophil degranulation; • positive regulation of chemokine (C-C motif) ligand 5 production; • positive regulation of interleukin-18-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	353376
	225471
	ENSG00000243414
	ENSMUSG00000056130
	Q86XR7
	Q8BJQ4
	NM_021649
	NM_173394
	NP_067681
	NP_775570
	Wikidata
View/Edit Human	View/Edit Mouse

TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene.^[5]

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM]^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000243414 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056130 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2".

Sullivan C, Postlethwait JH, Lage CR, et al. (2007). "Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates". J. Immunol. 178 (7): 4517–27. doi:10.4049/jimmunol.178.7.4517. PMID 17372010.
Rowe DC, McGettrick AF, Latz E, et al. (2006). "The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6299–304. doi:10.1073/pnas.0510041103. PMC 1458872. PMID 16603631.
Yamamoto M, Sato S, Hemmi H, et al. (2003). "TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway". Nat. Immunol. 4 (11): 1144–50. doi:10.1038/ni986. PMID 14556004.
Oshiumi H, Sasai M, Shida K, et al. (2004). "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta". J. Biol. Chem. 278 (50): 49751–62. doi:10.1074/jbc.M305820200. PMID 14519765.
Fitzgerald KA, Rowe DC, Barnes BJ, et al. (2003). "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF". J. Exp. Med. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000243414 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056130 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] 1 2 "Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2".

TICAM2

References

Further reading