TFDP2

TFDP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CF7
Identifiers
Aliases	TFDP2, DP2, transcription factor Dp-2
External IDs	MGI: 107167 HomoloGene: 4578 GeneCards: TFDP2
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	142,149,544 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	96,323,646 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding; • DNA binding; • transcription factor binding; • protein binding; • transcription cofactor activity; • protein domain specific binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding;
Cellular component	• cell nucleus; • transcription factor complex; • nucleoplasm; • mitochondrion; • RNA polymerase II transcription factor complex;
Biological process	• regulation of transcription from RNA polymerase II promoter; • cell cycle; • negative regulation of transcription, DNA-templated; • regulation of transcription, DNA-templated; • mitotic cell cycle; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • heart development; • transcription, DNA-templated; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • regulation of transcription involved in G1/S transition of mitotic cell cycle; • transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter; • negative regulation of G0 to G1 transition; • regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	7029
	211586
	ENSG00000114126
	ENSMUSG00000032411
	Q14188
	Q64163
NM_001178138; NM_001178139; NM_001178140; NM_001178141; NM_001178142;
	NM_006286
NM_001184706; NM_001184708; NM_001184709; NM_001184710; NM_001184711;
	NM_178667
NP_001171609; NP_001171610; NP_001171611; NP_001171612; NP_001171613;
	NP_006277
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000114126 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032411 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Zhang Y, Chellappan SP (Jul 1995). "Cloning and characterization of human DP2, a novel dimerization partner of E2F". Oncogene. 10 (11): 2085–93. PMID 7784053.
↑ Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics. 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID 9027491.
↑ "Entrez Gene: TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)".

Wu CL, Zukerberg LR, Ngwu C, et al. (1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC 230484. PMID 7739537.
Rogers KT, Higgins PD, Milla MM, et al. (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. doi:10.1073/pnas.93.15.7594. PMC 38791. PMID 8755520.
Loiseau L, Pasteau S, Brun G (1998). "Molecular cloning and expression pattern of the DP members of the chicken E2F transcription factor". Gene Expr. 6 (5): 259–73. PMID 9368098.
Trimarchi JM, Fairchild B, Verona R, et al. (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. doi:10.1073/pnas.95.6.2850. PMC 19658. PMID 9501179.
Gaubatz S, Wood JG, Livingston DM (1998). "Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9190–5. doi:10.1073/pnas.95.16.9190. PMC 21314. PMID 9689056.
Zheng N, Fraenkel E, Pabo CO, Pavletich NP (1999). "Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F–DP". Genes Dev. 13 (6): 666–74. doi:10.1101/gad.13.6.666. PMC 316551. PMID 10090723.
Korz C, Pscherer A, Benner A, et al. (2002). "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood. 99 (12): 4554–61. doi:10.1182/blood.V99.12.4554. PMID 12036888.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Park KK, Deok Ahn J, Lee IK, et al. (2003). "Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP". Biochem. Biophys. Res. Commun. 308 (4): 689–97. doi:10.1016/S0006-291X(03)01455-4. PMID 12927774.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000114126 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032411 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid7784053-5] Zhang Y, Chellappan SP (Jul 1995). "Cloning and characterization of human DP2, a novel dimerization partner of E2F". Oncogene. 10 (11): 2085–93. PMID 7784053.

[pmid9027491-6] Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics. 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID 9027491.

[entrez-7] "Entrez Gene: TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)".

TFDP2

References

Further reading