TERF2IP

TERF2IP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FEX, 3K6G, 4RQI
Identifiers
Aliases	TERF2IP, DRIP5, RAP1, TERF2 interacting protein
External IDs	MGI: 1929871 HomoloGene: 10357 GeneCards: TERF2IP
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	75,761,872 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	112,020,528 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • telomeric DNA binding; • protein binding; • G-rich strand telomeric DNA binding; • phosphatase binding;
Cellular component	• nuclear telomere cap complex; • nuclear envelope; • chromosome; • shelterin complex; • chromosome, telomeric region; • nuclear chromosome; • Mre11 complex; • nuclear chromosome, telomeric region; • cell nucleus; • nucleoplasm; • cytosol; • nuclear body; • cytoplasm;
Biological process	• negative regulation of DNA recombination at telomere; • telomere maintenance via telomerase; • protection from non-homologous end joining at telomere; • regulation of double-strand break repair via homologous recombination; • transcription, DNA-templated; • positive regulation of peptidyl-serine phosphorylation; • protein localization to chromosome, telomeric region; • positive regulation of protein acetylation; • telomere maintenance via telomere lengthening; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • telomere maintenance; • telomere capping; • negative regulation of protein phosphorylation; • regulation of transcription, DNA-templated; • regulation of telomere maintenance; • negative regulation of telomere maintenance; • positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	54386
	57321
	ENSG00000166848
	ENSMUSG00000033430
	Q9NYB0
	Q91VL8
	NM_018975
	NM_020584
	NP_061848
	NP_065609
	Wikidata
View/Edit Human	View/Edit Mouse

Telomeric repeat-binding factor 2-interacting protein 1 is a protein that in humans is encoded by the TERF2IP gene.^[5]^[6]

Interactions

TERF2IP has been shown to interact with Ku80,^[7] Rad50^[7] and TERF2.^[5]^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166848 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033430 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Li B, Oestreich S, de Lange T (July 2000). "Identification of human Rap1: implications for telomere evolution". Cell. 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490.
↑ "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein".
1 2 3 O'Connor, Matthew S; Safari Amin; Liu Dan; Qin Jun; Songyang Zhou (July 2004). "The human Rap1 protein complex and modulation of telomere length". J. Biol. Chem. United States. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. ISSN 0021-9258. PMID 15100233.
↑ Zhu, X D; Küster B; Mann M; Petrini J H; de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nat. Genet. UNITED STATES. 25 (3): 347–52. doi:10.1038/77139. ISSN 1061-4036. PMID 10888888.

Zhu XD, Küster B, Mann M, et al. (2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nat. Genet. 25 (3): 347–52. doi:10.1038/77139. PMID 10888888.
Hanaoka S, Nagadoi A, Yoshimura S, et al. (2001). "NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains". J. Mol. Biol. 312 (1): 167–75. doi:10.1006/jmbi.2001.4924. PMID 11545594.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Loayza D, De Lange T (2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013–8. Bibcode:2003Natur.423.1013L. doi:10.1038/nature01688. PMID 12768206.
Li B, de Lange T (2004). "Rap1 affects the length and heterogeneity of human telomeres". Mol. Biol. Cell. 14 (12): 5060–8. doi:10.1091/mbc.E03-06-0403. PMC 284807. PMID 14565979.
Zhu XD, Niedernhofer L, Kuster B, et al. (2004). "ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes". Mol. Cell. 12 (6): 1489–98. doi:10.1016/S1097-2765(03)00478-7. PMID 14690602.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
O'Connor MS, Safari A, Liu D, et al. (2004). "The human Rap1 protein complex and modulation of telomere length". J. Biol. Chem. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. PMID 15100233.
Liu D, Safari A, O'Connor MS, et al. (2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nat. Cell Biol. 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ye JZ, Donigian JR, van Overbeek M, et al. (2004). "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres". J. Biol. Chem. 279 (45): 47264–71. doi:10.1074/jbc.M409047200. PMID 15316005.
Liu D, O'Connor MS, Qin J, Songyang Z (2005). "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins". J. Biol. Chem. 279 (49): 51338–42. doi:10.1074/jbc.M409293200. PMID 15383534.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Antoine K, Ferbus D, Kolahgar G, et al. (2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1". J. Cell. Biochem. 95 (4): 763–8. doi:10.1002/jcb.20487. PMID 15838871.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Wu Y, Zacal NJ, Rainbow AJ, Zhu XD (2007). "XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening". DNA Repair (Amst.). 6 (2): 157–66. doi:10.1016/j.dnarep.2006.09.005. PMID 17055345.
Bae NS, Baumann P (2007). "A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends". Mol. Cell. 26 (3): 323–34. doi:10.1016/j.molcel.2007.03.023. PMID 17499040.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166848 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033430 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10850490-5] 1 2 Li B, Oestreich S, de Lange T (July 2000). "Identification of human Rap1: implications for telomere evolution". Cell. 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490.

[entrez-6] "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein".

[pmid15100233-7] 1 2 3 O'Connor, Matthew S; Safari Amin; Liu Dan; Qin Jun; Songyang Zhou (July 2004). "The human Rap1 protein complex and modulation of telomere length". J. Biol. Chem. United States. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. ISSN 0021-9258. PMID 15100233.

[pmid10888888-8] Zhu, X D; Küster B; Mann M; Petrini J H; de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nat. Genet. UNITED STATES. 25 (3): 347–52. doi:10.1038/77139. ISSN 1061-4036. PMID 10888888.

TERF2IP

Interactions

References

Further reading