TELO2

TELO2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PSI
Identifiers
Aliases	TELO2, CLK2, TEL2, telomere maintenance 2, YHFS
External IDs	MGI: 1918968 HomoloGene: 41107 GeneCards: TELO2
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	1,510,457 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	25,115,967 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein complex scaffold activity; • Hsp90 protein binding; • protein binding; • protein kinase binding; • macromolecular complex binding; • telomeric DNA binding;
Cellular component	• cytoplasm; • chromosome, telomeric region; • TORC1 complex; • TORC2 complex; • intracellular; • membrane; • nuclear periphery; • cell nucleus; • chromosome; • cytosol; • nuclear body; • nuclear chromosome, telomeric region; • ASTRA complex;
Biological process	• positive regulation of TORC1 signaling; • protein stabilization; • regulation of TOR signaling; • positive regulation of TORC2 signaling; • positive regulation of protein serine/threonine kinase activity; • telomere maintenance;
	Sources:Amigo / QuickGO
Orthologs
	9894
	71718
	ENSG00000100726
	ENSMUSG00000024170
	Q9Y4R8
	Q9DC40
	NM_016111; NM_001351846
	NM_001163661; NM_027880
	NP_057195; NP_001338775
	NP_001157133; NP_082156
	Wikidata
View/Edit Human	View/Edit Mouse

Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.^[5]^[6]^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100726 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024170 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.
↑ "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".

Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100726 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024170 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid11230166-6] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[pmid12670948-7] Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.

[entrez-8] "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".

TELO2

References

Further reading