TCL1A

TCL1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTCL1A, TCL1, T-cell leukemia/lymphoma 1A, T cell leukemia/lymphoma 1A
External IDsMGI: 1097166 HomoloGene: 7565 GeneCards: TCL1A
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q32.13Start95,709,967 bp[1]
End95,714,196 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8115

21432

Ensembl

ENSG00000100721

ENSMUSG00000041359

UniProt

P56279

P56280

RefSeq (mRNA)

NM_001098725
NM_021966

NM_001289468
NM_009337
NM_001309484
NM_001309485

RefSeq (protein)

NP_001092195
NP_068801
NP_001092195.1
NP_068801.1

NP_001276397
NP_001296413
NP_001296414
NP_033363

Location (UCSC)Chr 14: 95.71 – 95.71 MbChr 12: 105.22 – 105.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.[5][6][7]

Interactions

TCL1A has been shown to interact with AKT1[8][9][10] and AKT2.[8][9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100721 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041359 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A. 86 (2): 602–6. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489.
  6. ↑ Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A. 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072.
  7. ↑ "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A".
  8. 1 2 Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
  9. 1 2 Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
  10. ↑ French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.

Further reading

  • Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia". Oncogene. 20 (40): 5638–43. doi:10.1038/sj.onc.1204596. PMID 11607815.
  • Pekarsky Y, Zanesi N, Aqeilan R, Croce CM (2004). "Tcl1 as a model for lymphomagenesis". Hematol. Oncol. Clin. North Am. 18 (4): 863–79, ix. doi:10.1016/j.hoc.2004.04.007. PMID 15325703.
  • Noguchi M, Ropars V, Roumestand C, Suizu F (2007). "Proto-oncogene TCL1: more than just a coactivator for Akt". FASEB J. 21 (10): 2273–84. doi:10.1096/fj.06-7684com. PMID 17360849.
  • Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM (1995). "Characterization and localization of the TCL-1 oncogene product". Cancer Res. 54 (24): 6297–301. PMID 7987816.
  • Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H (1998). "Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology". Structure. 6 (2): 147–55. doi:10.1016/S0969-2126(98)00017-3. PMID 9519406.
  • Takizawa J, Suzuki R, Kuroda H, Utsunomiya A, Kagami Y, Joh T, Aizawa Y, Ueda R, Seto M (1998). "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia". Jpn. J. Cancer Res. 89 (7): 712–8. doi:10.1111/j.1349-7006.1998.tb03275.x. PMID 9738977.
  • Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM (1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2949–51. doi:10.1073/pnas.96.6.2949. PMC 15875. PMID 10077617.
  • Laine J, Künstle G, Obata T, Sha M, Noguchi M (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
  • Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
  • French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.
  • Fears S, Chakrabarti SR, Nucifora G, Rowley JD (2002). "Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression". Cancer Genet. Cytogenet. 135 (2): 110–9. doi:10.1016/S0165-4608(01)00655-0. PMID 12127395.
  • Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC, Teitell MA (2002). "Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14392–7. doi:10.1073/pnas.212410199. PMC 137894. PMID 12381789.
  • French SW, Malone CS, Shen RR, Renard M, Henson SE, Miner MD, Wall R, Teitell MA (2003). "Sp1 transactivation of the TCL1 oncogene". J. Biol. Chem. 278 (2): 948–55. doi:10.1074/jbc.M207166200. PMID 12421830.
  • Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D (2004). "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin". Blood. 101 (12): 5007–9. doi:10.1182/blood-2002-10-3297. PMID 12576313.
  • Kiss C, Nishikawa J, Takada K, Trivedi P, Klein G, Szekely L (2003). "T cell leukemia I oncogene expression depends on the presence of Epstein–Barr virus in the virus- carrying Burkitt lymphoma lines". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4813–8. doi:10.1073/pnas.0730710100. PMC 153638. PMID 12672960.


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