TAF1C

TAF1C
Identifiers
AliasesTAF1C, MGC:39976, SL1, TAFI110, TAFI95, TATA-box binding protein associated factor, RNA polymerase I subunit C
External IDsMGI: 109576 HomoloGene: 21163 GeneCards: TAF1C
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q24.1Start84,177,847 bp[1]
End84,187,070 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9013

21341

Ensembl

ENSG00000103168

ENSMUSG00000031832

UniProt

Q15572

Q6PDZ2

RefSeq (mRNA)

NM_021441

RefSeq (protein)

NP_067416

Location (UCSC)Chr 16: 84.18 – 84.19 MbChr 8: 119.6 – 119.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.[5][6]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[6]

Interactions

TAF1C has been shown to interact with UBTF.[7][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000103168 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031832 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123.
  6. 1 2 "Entrez Gene: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa".
  7. ↑ Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. doi:10.1073/pnas.231071698. PMC 61092. PMID 11698641.
  8. ↑ Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176.

Further reading

  • Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. doi:10.1159/000015592. PMID 10894955.
  • Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
  • Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
  • Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
  • Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID 15723054.
  • Friedrich JK, Panov KI, Cabart P, Russell J, Zomerdijk JC (2005). "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter". J. Biol. Chem. 280 (33): 29551–8. doi:10.1074/jbc.M501595200. PMC 3858828. PMID 15970593.
  • Zhang C, Comai L, Johnson DL (2005). "PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex". Mol. Cell. Biol. 25 (16): 6899–911. doi:10.1128/MCB.25.16.6899-6911.2005. PMC 1190253. PMID 16055704.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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