TACC2

TACC2
Identifiers
AliasesTACC2, AZU-1, ECTACC, transforming acidic coiled-coil containing protein 2
External IDsMGI: 1928899 HomoloGene: 5087 GeneCards: TACC2
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q26.13Start121,989,174 bp[1]
End122,254,545 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10579

57752

Ensembl

ENSG00000138162

ENSMUSG00000030852

UniProt

O95359
Q4VXL4

Q9JJG0

RefSeq (mRNA)

NM_001004468
NM_021314
NM_206856
NM_001347637

RefSeq (protein)

NP_001004468
NP_001334566
NP_067289
NP_996738

Location (UCSC)Chr 10: 121.99 – 122.25 MbChr 7: 130.58 – 130.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2 gene.[5][6]

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138162 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030852 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH (Apr 2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases". Oncogene. 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID 14767476.
  6. 1 2 "Entrez Gene: TACC2 transforming, acidic coiled-coil containing protein 2".

Further reading

  • Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics. 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID 10366448.
  • Still IH, Hamilton M, Vince P, et al. (1999). "Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon". Oncogene. 18 (27): 4032–8. doi:10.1038/sj.onc.1202801. PMID 10435627.
  • Gergely F, Kidd D, Jeffers K, et al. (2000). "D–TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo". EMBO J. 19 (2): 241–52. doi:10.1093/emboj/19.2.241. PMC 305558. PMID 10637228.
  • Chen HM, Schmeichel KL, Mian IS, et al. (2000). "AZU-1: A Candidate Breast Tumor Suppressor and Biomarker for Tumor Progression". Mol. Biol. Cell. 11 (4): 1357–67. doi:10.1091/mbc.11.4.1357. PMC 14852. PMID 10749935.
  • Gergely F, Karlsson C, Still I, et al. (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352–7. doi:10.1073/pnas.97.26.14352. PMC 18922. PMID 11121038.
  • Pu JJ, Li C, Rodriguez M, Banerjee D (2001). "Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells". Cytokine. 13 (3): 129–37. doi:10.1006/cyto.2000.0812. PMID 11161455.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lauffart B, Gangisetty O, Still IH (2003). "Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2". Genomics. 81 (2): 192–201. doi:10.1016/S0888-7543(02)00039-3. PMID 12620397.
  • Sadek CM, Pelto-Huikko M, Tujague M, et al. (2004). "TACC3 expression is tightly regulated during early differentiation". Gene Expr. Patterns. 3 (2): 203–11. doi:10.1016/S1567-133X(02)00066-2. PMID 12711550.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
  • Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P (2004). "Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms". BMC Evol. Biol. 4: 16. doi:10.1186/1471-2148-4-16. PMC 441373. PMID 15207008.
  • Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.


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