Synthetic ribosome

Synthetic ribosomes are artificial small-molecules that can synthesize peptides in a sequence-specific matter.[1]

David Alan Leigh's lab built synthetic ribosome using a chemical structure based on a rotaxane.[2]

The Cédric Orelle research group created ribosomes with tethered and inseparable subunits (or Ribo-T).[3]

References

  1. ↑ Sleator, RD (2013). "Synthetic ribosomes". Bioengineered. 4: 63–4. doi:10.4161/bioe.23640. PMC 3609622. PMID 23324614.
  2. ↑ Lewandowski, B; De Bo, G; Ward, JW; Papmeyer, M; Kuschel, S; Aldegunde, MJ; Gramlich, PM; Heckmann, D; Goldup, SM; D'Souza, DM; Fernandes, AE; Leigh, DA. "Sequence-specific peptide synthesis by an artificial small-molecule machine". Science. 339: 189–93. doi:10.1126/science.1229753. PMID 23307739.
  3. ↑ "Protein synthesis by ribosomes with tethered subunits". Nature. 524: 119–124. doi:10.1038/nature14862. Retrieved July 29, 2015.
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