Susan Gottesman

Susan Gottesman
NIH photo of Susan Gottesman
Born (1945-05-19) May 19, 1945
New York, New York
Residence Bethesda, Maryland
Alma mater
Known for
  • Bacterial small RNAs
  • Proteases and their function in ATP-hydrolysis.
  • Discovered central features of new family of proteases requiring energy for their function in the form of ATP-hydrolysis.
Scientific career
Fields
  • Genetics
  • Microbial biology
Institutions
Thesis  (1972)

Susan Gottesman is microbiologist at the National Cancer Institute (NCI), which is part of the National Institutes of Health. She is a pioneer in the area of biological regulation in which enzymes that destroy specific other proteins, called proteases, play a central role inside the cell. She discovered and elucidated the central features of a new family of proteases that require energy for their function in the form of ATP-hydrolysis.[1] She has also played a major role in the discovery and characterization of bacterial small RNAs.

Life

Gottesman was born on May 19, 1945, in New York. Her father was trained as an accountant and ran a company that made rotisseries and other small appliances. Her mother was a high school teacher and later became a guidance counselor.[1]

Gottesman received a B.A. in biochemical sciences in 1967 from Radcliffe College and a Ph.D. in microbiology from Harvard University in 1972. She did her postdoctoral training from 1971 to 1974 in NCI's Laboratory of Molecular Biology. From 1974 to 1976, she was a research associate at the Massachusetts Institute of Technology before returning as a senior investigator to NCI’s Laboratory of Molecular Biology. She is co-chief of that Laboratory and head of its Biochemical Genetics Section.[2]

Awards and honors

Selected publications

  • Battesti, A; Hoskins, JR; Tong, S; Milanesio, P; Mann, JM; Kravats, A; Tsegaye, YM; Bougdour, A; Wickner, S; Gottesman, S (December 15, 2013). "Anti-adaptors provide multiple modes for regulation of the RssB adaptor protein". Genes & Development. 27 (24): 2722–35. doi:10.1101/gad.229617.113. PMC 3877760. PMID 24352426.
  • Zhang, A; Schu, DJ; Tjaden, BC; Storz, G; Gottesman, S (October 9, 2013). "Mutations in interaction surfaces differentially impact E. coli Hfq association with small RNAs and their mRNA targets". Journal of Molecular Biology. 425 (19): 3678–97. doi:10.1016/j.jmb.2013.01.006. PMC 3640674. PMID 23318956.
  • Soper, T; Mandin, P; Majdalani, N; Gottesman, S; Woodson, SA (May 25, 2010). "Positive regulation by small RNAs and the role of Hfq". Proceedings of the National Academy of Sciences of the United States of America. 107 (21): 9602–7. doi:10.1073/pnas.1004435107. PMC 2906882. PMID 20457943.
  • Battesti, A; Majdalani, N; Gottesman, S (2011). "The RpoS-mediated general stress response in Escherichia coli". Annual Review of Microbiology. 65: 189–213. doi:10.1146/annurev-micro-090110-102946. PMID 21639793.
  • De Lay, N; Gottesman, S (November 2012). "A complex network of small non-coding RNAs regulate motility in Escherichia coli". Molecular Microbiology. 86 (3): 524–38. doi:10.1111/j.1365-2958.2012.08209.x. PMID 22925049.

References

  1. 1 2 Gottesman, Susan; Gant, Jason (October 1, 2008). "NCI Laboratory of Molecular Biology Oral History Project" (PDF).
  2. ↑ Gottesman, Susan. "Susan Gottesman, Ph.D."
  3. ↑ National Academy of Sciences. "Susan Gottesman". National Academy of Sciences. Retrieved March 15, 2015.
  4. ↑ American Academy of Arts & Sciences. "Dr. Susan Gottesman". American Academy of Arts & Sciences. Retrieved March 15, 2015.
  5. ↑ American Society of Microbiology (2009). "American Academy of Microbiology (AAM) 2009 Election Results". Microbe News (April). Retrieved March 15, 2015.
  6. ↑ American Society of Microbiology (2011). "ASM News, 2011 General Meeting Awards". Microbe Magazine (April). Retrieved March 15, 2015.
  7. ↑ National Academy of Sciences. "Selman A. Waksman Award in Microbiology". National Academy of Sciences. Retrieved March 15, 2015.
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