Streptomyces tsukubaensis

Streptomyces tsukubaensis
Scientific classification
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Actinomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: S. tsukubaensis
Binomial name
Streptomyces tsukubaensis

Streptomyces tsukubaensis is a species of actinobacteria. It produces the immunosuppressive drug tacrolimus.[1][2] Tacrolimus was first isolated from S. tsukubaensis in 1984.[3]

References

  1. ↑ Pritchard D (2005). "Sourcing a chemical succession for cyclosporin from parasites and human pathogens". Drug Discov Today. 10 (10): 688–91. doi:10.1016/S1359-6446(05)03395-7. PMID 15896681. Supports source organism, but not team information
  2. ↑ Blažič, Marko; Kosec, Gregor; Baebler, Špela; Gruden, Kristina; Petković, Hrvoje (2015). "Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis". Microbial Cell Factories. 14. doi:10.1186/s12934-015-0352-z.
  3. ↑ Pirsch, JD; Miller, J; Deierhoi, MH; Vincenti, F; Filo, RS (15 April 1997). "A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group" (PDF). Transplantation. 63 (7): 977–83. PMID 9112351. Retrieved 28 August 2018.

Further reading

Du, W; Huang, D; Xia, M; Wen, J; Huang, M (July 2014). "Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies". Journal of industrial microbiology & biotechnology. 41 (7): 1131–43. doi:10.1007/s10295-014-1450-3. PMID 24788378.


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