Srp receptor alpha subunit

SRPRA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FH5, 2GO5, 5L3Q
Identifiers
Aliases	SRPRA, DP, Sralpha, SRPR, SRP receptor alpha subunit, SRP receptor subunit alpha
External IDs	MGI: 1914648 HomoloGene: 2364 GeneCards: SRPRA
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 126,262,919 bp[1] End 126,269,144 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 35,200,175 bp[2] End 35,247,973 bp[2]
Gene ontology Molecular function • nucleotide binding • signal recognition particle binding • GTP binding • GTPase activity • RNA binding Cellular component • signal recognition particle receptor complex • integral component of membrane • extracellular exosome • endoplasmic reticulum membrane • endoplasmic reticulum • membrane Biological process • IRE1-mediated unfolded protein response • intracellular protein transport • cotranslational protein targeting to membrane • SRP-dependent cotranslational protein targeting to membrane • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6734	67398
Ensembl	ENSG00000182934	ENSMUSG00000032042
UniProt	P08240	Q9DBG7
RefSeq (mRNA)	NM_003139 NM_001177842	NM_026130
RefSeq (protein)	NP_001171313 NP_003130	NP_080406
Location (UCSC)	Chr 11: 126.26 – 126.27 Mb	Chr 9: 35.2 – 35.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

SRP receptor alpha subunit is a protein that in humans is encoded by the SRPRA gene. ^[5]

Function

The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.