SroC RNA

sroC RNA
Identifiers
Symbol sroC
Rfam RF00369
Other data
RNA type Gene; sRNA
Domain(s) Bacteria
SO 0000655
PDB structures PDBe

The bacterial SroC RNA is a non-coding RNA gene of around 160 nucleotides in length. SroC is found in several enterobacterial species.[1] This RNA interacts with the Hfq protein.

SroC acts as a ‘sponge,’ and base pairs with and regulates activity of the sRNA GcvB. This interaction triggers the degradation of GcvB by RNase E, alleviating the GcvB-mediated mRNA repression of other amino acid-related transport and metabolic genes.[2][3]

References

  1. ↑ Vogel, J; Bartels V; Tang TH; Churakov G; Slagter-Jager JG; Huttenhofer A; Wagner EG (2003). "RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria". Nucleic Acids Res. 31 (22): 6435&ndash, 6443. doi:10.1093/nar/gkg867. PMC 275561. PMID 14602901.
  2. ↑ Miyakoshi, Masatoshi; Chao, Yanjie; Vogel, Jörg (2015-06-03). "Cross talk between ABC transporter mRNAs via a target mRNA-derived sponge of the GcvB small RNA". The EMBO Journal. 34 (11): 1478–1492. doi:10.15252/embj.201490546. ISSN 1460-2075. PMC 4474525. PMID 25630703.
  3. ↑ Azam, Muhammad S.; Vanderpool, Carin K. (2015-06-03). "Talk among yourselves: RNA sponges mediate cross talk between functionally related messenger RNAs". The EMBO Journal. 34 (11): 1436–1438. doi:10.15252/embj.201591492. ISSN 1460-2075. PMC 4474520. PMID 25916829.


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