Siddhartha Roy

Siddhartha Roy
Born (1954-04-01)1 April 1954
West Bengal, India
Nationality Indian
Alma mater
Known for Studies on gene expression using the operator-repressor system of bacteriophage lambda
macromolecular interactions leading to high fidelity of protein synthesis
Awards 1999 Shanti Swarup Bhatnagar Prize
USDHHS Meritorious Service Award
Scientific career
Fields
Institutions
Doctoral advisor Roberta Colman

Siddhartha Roy (born 1954) is an Indian structural biologist, biophysicist, former Director of the Indian Institute of Chemical Biology[1] and the current Director (Officiating) of Bose Institute. Widely known for his studies on bacteriophage lambda and protein synthesis,[2] he is an elected fellow of the Indian Academy of Sciences[3] and the Indian National Science Academy.[4] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian Science awards, in 1999, for his contributions to Biological sciences.[5]

Biography

Born on 1 April 1954 in the Indian state of West Bengal, Siddhartha Roy completed his schooling from Ballygunge Government High School and then obtained an honours degree in chemistry (BSc Hons) from Presidency College, Calcutta in 1974 and did his doctoral studies at the University of Delaware under the guidance of Prof. Roberta Colman to secure a PhD in 1981.[4] His post-doctoral studies were at Brandeis University at the laboratory of Prof. Alfred Redfield (1981–82) and at the National Institutes of Health (1982–86). Returning to India in 1986, he joined Bose Institute, Kolkata as a Senior Lecturer in the department of Biophysics.[4] He served the Institute till 2004 holding positions of Reader and then Professor of Biophysics when he moved to the Indian Institute of Chemical Biology (IICB) as its Director.[6] After completing 10 years as the Director of IICB, he returned to Bose Institute in 2014 as a Senior Professor and Dean of studies. While at IICB, he has served the nation in several different high level capacities such as the Founder-Director-in-charge of the National Institute of Pharmaceutical Education and Research, Kolkata (NIPER) (2007–14), the Cluster Director of 11 Biological institutes of the Council of Scientific and Industrial Research (CSIR) (2009–14), member of the Governing Body of the CSIR and as a Visiting Professor at Osaka University (2012).[7] He has served as the President of the West Bengal Academy of Science and Technology. He is the Founder-President of the Chemical Biology Society of India. He currently serves as a member of the Board of Directors of the International Chemical Biology Society. He also served as the Director (officiating) of Bose Institute during the critical Centenary year.

Legacy

Roy's researches during his stint in the US was on protein folding and nuclear magnetic resonance studies of DNA[4] and those researches identified the first hydropathy model which helped in predicting the exteriors and interiors of proteins by analyzing sequence information.[7] He is also reported to have performed the complete assignment of a nucleic acid imino proton spectra using Nuclear Overhauser Effect, regio-specific isotope labeling of sugars in nucleic acids and working along with Ad Bax and R. H. Griffey, developed an indirect 2D-NMR detection method, all reported to be for the first time.[7] Later focusing his attention on bacteriophage lambda, he studied the gene expression of the bacterial virus using its operator-repressor system.[8] Through his collaborative work with Sankar Adhya in 1998, he elucidated the role of differential contact in the transcription regulation mechanism and demonstrated the theory in many genetic regulatory circuits.[4] His current work is focused on peptide therapeutics[7] and he holds patents for some of his work.[9][10][11]

Roy has published his research work through a number of articles published in peer-reviewed journals[note 1] and ResearchGate, an online repository of scientific papers, has listed 155 of them.[12] He is a joint editor of Subcellular Biochemistry, volume on Proteins: Structure, Function, and Engineering published by Plenum Press, New York, USA. He has guided around 30 scholars in their doctoral studies.[4] When the Chemical Biology Society of India was formed in 2013, he became its founder president and holds the position.[13] He is a former president of the West Bengal Academy of Science and Technology and is its incumbent vice president.[14]

Awards and honours

The Indian Academy of Sciences elected Roy as their fellow in 1996[3] and the Council of Scientific and Industrial Research awarded him the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards, in 1999.[5] A recipient of the Meritorious Service Award of the United States Department of Health and Human Services, he was elected by the Indian National Science Academy as a fellow in 2005.[4] In 2007, he was elected as a fellow of the West Bengal Academy of Science and Technology[15] and he received the J. C. Bose National Fellowship of the Science and Engineering Research Board [16] as well as the Tata Innovation Fellowship of the Department of Biotechnology the same year.[7] He was also a member of Guha Research Conference during the years 1992 and 2012.[7] He is a Fellow of the Royal Society of Chemistry, UK and has been elected a member of The World Academy of Sciences (FTWAS).

Selected bibliography

  • Gitashri Naiya, Paromita Raha, Manas Mondal, Uttam Pal, Rajesh Saha, Susobhan Choudhury, Subrata Batabyal, Samir Kumar Pal, Dhananjay Bhattacharyya, Nakul Chandra Maiti, Siddhartha Roy, (June 2016). "Conformational Selection Underpins Recognition of Multiple DNA sequences by Proteins and Consequent Functional Actions". Physical Chemistry Chemical Physics. 18 (31): 21618–21628. doi:10.1039/C6CP03278H.
  • Samir Kumar Pal, Susobhan Choudhury, Basusree Ghosh, Priya Singh, Raka Ghosh, Siddhartha Roy (June 2016). "Ultrafast Differential Flexibility of Cro-protein Binding Domains of Two Operator DNAs with Different Sequences". Physical Chemistry Chemical Physics. 18 (27): 17983–17990. doi:10.1039/C6CP02522F.
  • Sk Kayum Alam, Vinod Yadav, Swati Bajaj, Arindam Datta, Shamit Kumar Dutta, Madhumita Bhattacharyya, Santanu Bhattacharya, Subrata Debnath, Siddhartha Roy, Lisa A Boardman, Thomas Smyrk, Julian R. Molina, Saikat Chakrabarty, Shantanu Chowdhury, Debabrata Mukhopadhyay, Susanta Roychoudhury (April 2016). "DNA Damage-Induced Ephrin-B2 Reverse Signaling Promotes Chemoresistance and Drives EMT in Colorectal Carcinoma Harboring Mutant p53". Cell Death and Differentiation. 23 (4): 707–722. doi:10.1038/cdd.2015.133. PMC 4986638. PMID 26494468.
  • Gitashri Naiya, Stephanie Kaypee, Tapas Kundu, Siddhartha Roy (March 2015). "A Constrained Helical Peptide Against S100A4 Inhibits Cell Motility in Tumor Cells". Chemical Biology & Drug Design. 86 (4): 945–950. doi:10.1111/cbdd.12553.
  • Tanjore Balganesh, Tapas Kundu, Tushar Kanti Chakraborty, Siddhartha Roy (July 2014). "Drug Discovery Research in India: Current State and Future Prospects". ACS Medicinal Chemistry Letters. 5 (7): 724–6. doi:10.1021/ml500183c. PMC 4094254.
  • Siddhartha Roy, Tapas Kundu (February 2014). "Gene regulatory networks and epigenetic modifications in cell differentiation". International Union of Biochemistry and Molecular Biology Life. 66 (2): 100–109. doi:10.1002/iub.1249.
  • Siddhartha Roy, Piya Ghosh, Neeladri Roy, Abhishek Mazumder, Koushik Roy, Asit Kumar Manna, Shampa Mallick, Israr Ahmed (May 2012). "Peptide based Molecules as Protein-Protein Interaction Inhibitors: Tools for Chemical Genetics and Therapy". Current Chemical Biology. 6: 145–163. doi:10.2174/2212796811206020145.

Patents

The list is incomplete.

  • Sibabrata Mukhopadhyay, Mumu Chakraborty, Arun Bandyopadhyay, Dipak Kar, Tanima Banerjee, Aditya Konar, Debaprasad Jana, Siddhartha Roy, Santu Bandyopadhyay, Balram Ghosh, Mabalirajan Ulaganathan, Rakesh Johri, Subhash Sharma, Gurdarshan Singh, Bholanath Paul, Vasanta Madhava Sharma Gangavaram, Jhillu Singh Yadav, Radha Krishna Palakodety (August 2013). "Method for treatment of bronchial asthma (Patent US8519154B2)".
  • Sujoy K Das Gupta, Abhik Saha, Archana Sharma, Siddhartha Roy, Bhabatarak Bhattacharya (January 2012). "Peptide antagonists for inhibiting heat shock protein (Hsp 16.3) of Mycobacterium tuberculosis (Patent 7569537)". ResearchGate. Retrieved 15 October 2016.
  • S. Bandyopadhay, B. Ghosh, Parasuraman Jaisankar, Bikas C Pal, Siddhartha Roy, Nath Paul, Arjun Ram, U. Mabalirajan, Nahid Ali, Arun Bandyopadhyay, Aditya Konar, J. B. Chakraborty, I. C. Mukherjee, Jaydeep Chaudhuri, Sanjit Kumar Mahato, A. Manna, Roma Sinha, Pradyot Bhattacharya, J. Vinayagam, Sudeshna Chowdhury (January 2012). "Substituted catechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma (WO Patent 2,012,140,574)". ResearchGate. doi:10.13140/RG.2.1.2784.6488. Retrieved 15 October 2016.
  • 1st S. Bandyopadhay, B. Ghosh, Parasuraman Jaisankar, Bikas C Pal, Siddhartha Roy, Nath Paul, Arjun Ram, U. Mabalirajan, Nahid Ali, Arun Bandyopadhyay, Aditya Konar, J. B. Chakraborty, I. C. Mukherjee, Jaydeep Chaudhuri, Sanjit Kumar Mahato, A. Manna, Roma Sinha, Pradyot Bhattacharya, J. Vinayagam, D. P. Jana, Sudeshna Chowdhury (January 2012). "Substituted catechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma (WO Patent 2,012,140,574.)". doi:10.13140/RG.2.1.2784.6488.
  • 1st Subhendu Bandyopadhyay, B. Ghosh, Parasuraman Jaisankar, Bikas C Pal, Siddhartha Roy, Nath Paul, Arjun Ram, U. Mabalirajan, Nahid Ali, Arun Bandyopadhyay, Aditya Konar, J. Bagchi Chakraborty, I. Choudhury Mukherjee, Jaydeep Chaudhuri, Sanjit Kumar Mahato, A. Manna, Roma Sinha, Pradyot Bhattacharya, J. Vinayagam, D. P. Jana, Sudeshna Chowdhury (April 2011). "Inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma (Patent 1032DEL2011)".

See also

Notes

  1. ↑ Please see Selected bibliography section

References

  1. ↑ "Siddhartha Roy on IICB". Indian Institute of Chemical Biology. 2016. Retrieved 14 October 2016.
  2. ↑ "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 5 October 2016.
  3. 1 2 "Fellow profile - Roy". Indian Academy of Sciences. 2016. Retrieved 6 October 2016.
  4. 1 2 3 4 5 6 7 "Indian fellow - Roy". Indian National Science Academy. 2016. Retrieved 11 October 2016.
  5. 1 2 "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 5 October 2016.
  6. ↑ "CV on IICB". Indian Institute of Chemical Biology. 2016. Retrieved 14 October 2016.
  7. 1 2 3 4 5 6 "Siddhartha Roy on Bose Institute". Bose Institute. 2016. Retrieved 14 October 2016.
  8. ↑ "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 34. Retrieved 5 October 2016.
  9. ↑ Sibabrata Mukhopadhyay, Mumu Chakraborty, Arun Bandyopadhyay, Dipak Kar, Tanima Banerjee, Aditya Konar, Debaprasad Jana, Siddhartha Roy, Santu Bandyopadhyay, Balram Ghosh, Mabalirajan Ulaganathan, Rakesh Johri, Subhash Sharma, Gurdarshan Singh, Bholanath Paul, Vasanta Madhava Sharma Gangavaram, Jhillu Singh Yadav, Radha Krishna Palakodety (August 2013). "Method for treatment of bronchial asthma (Patent US8519154B2)".
  10. ↑ Sujoy K Das Gupta, Abhik Saha, Archana Sharma, Siddhartha Roy, Bhabatarak Bhattacharya (January 2012). "Peptide antagonists for inhibiting heat shock protein (Hsp 16.3) of Mycobacterium tuberculosis (Patent 7569537)". ResearchGate. Retrieved 15 October 2016.
  11. ↑ S. Bandyopadhay, B. Ghosh, Parasuraman Jaisankar, Bikas C Pal, Siddhartha Roy, Nath Paul, Arjun Ram, U. Mabalirajan, Nahid Ali, Arun Bandyopadhyay, Aditya Konar, J. B. Chakraborty, I. C. Mukherjee, Jaydeep Chaudhuri, Sanjit Kumar Mahato, A. Manna, Roma Sinha, Pradyot Bhattacharya, J. Vinayagam, Sudeshna Chowdhury (January 2012). "Substituted catechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma (WO Patent 2,012,140,574)". ResearchGate. doi:10.13140/RG.2.1.2784.6488. Retrieved 15 October 2016.
  12. ↑ "Siddhartha Roy on ResearchGate". ResearchGate. 2016. Retrieved 15 October 2016.
  13. ↑ "Present Council CBS". Chemical Biology Society of India. 2016. Archived from the original on 2014-03-30. Retrieved 15 October 2016.
  14. ↑ "Present Council WAST". West Bengal Academy of Science and Technology. 2016. Retrieved 15 October 2016.
  15. ↑ "WAST fellows" (PDF). West Bengal Academy of Science and Technology. 2016. Retrieved 15 October 2016.
  16. ↑ "J. C. Bose National Fellowship" (PDF). Science and Engineering Research Board. 2016. Retrieved 15 October 2016.
  • "Patent applications by Siddhartha Roy, Kolkata". Patent listing. Patent Docs. 2016. Retrieved 15 October 2016.
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