Selenophosphate synthetase 1

SEPHS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEPHS1, SELD, SPS, SPS1, Selenophosphate synthetase 1
External IDsMGI: 1923580 HomoloGene: 56558 GeneCards: SEPHS1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p13Start13,317,424 bp[1]
End13,348,298 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22929

109079

Ensembl

ENSG00000086475

ENSMUSG00000026662

UniProt

P49903
Q5T5U7

Q8BH69

RefSeq (mRNA)

NM_001195602
NM_001195604
NM_012247

NM_175400

RefSeq (protein)

NP_001182531
NP_001182533
NP_036379

NP_780609
NP_001349636
NP_001349637
NP_001349638
NP_001349639

Location (UCSC)Chr 10: 13.32 – 13.35 MbChr 2: 4.88 – 4.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.[5][6]

This protein encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000086475 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026662 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Low SC; Harney JW; Berry MJ (Oct 1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem. 270 (37): 21659–64. doi:10.1074/jbc.270.37.21659. PMID 7665581.
  6. 1 2 "Entrez Gene: SEPHS1 selenophosphate synthetase 1".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Tamura T, Yamamoto S, Takahata M, et al. (2004). "Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation". Proc. Natl. Acad. Sci. U.S.A. 101 (46): 16162–7. doi:10.1073/pnas.0406313101. PMC 528966. PMID 15534230.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Saiki R, Nagata A, Kainou T, et al. (2005). "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans". FEBS J. 272 (21): 5606–22. doi:10.1111/j.1742-4658.2005.04956.x. PMID 16262699.
  • Chung HJ, Yoon SI, Shin SH, et al. (2006). "p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression". J. Cell. Physiol. 209 (1): 131–41. doi:10.1002/jcp.20714. PMID 16786570.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.