Seema Bhatnagar

Seema Bhatnagar
Native name सीमा श्रीवास्तव
Born Seema Srivastava
Lucknow
Nationality Indian
Other names Seema Srivastava
Citizenship Indian
Education Ph.D.(Chemistry)
Alma mater Central Drug Research Institute
Chaudhary Charan Singh University
Isabella Thoburn College
Known for Drug discovery
Spouse(s) 1
Children 2
Awards Senior Research Fellowship (Extended) by the Council of Scientific and Industrial Research, New Delhi. (06/99-12/99)
Scientific career
Fields Small Molecule Drug Discovery
Institutions Amity University, Noida
Thesis Syntheses of Possible Spermicidal Agents (1998)
Doctoral advisor Amiya Prasad Bhaduri[1]
Doctoral students Swati Kaushik;[2] Megha Rikhi[3]
Website http://www.amity.edu/aib/Faculty/Resumes/Seema-Bhatnagar.pdf

Seema Bhatnagar (born: Seema Srivastava; hindi: सीमा श्रीवास्तव) is an Indian scientist, working in the field of anticancer drug discovery.[4][5][6][7][8][9] She primarily works on synthetic chemistry approaches for targeted delivery of anticancer drugs in breast cancer.

Education

Seema Bhatnagar completed her B.Sc. in Chemistry, Biology and Zoology (1992), followed by M.Sc. in Organic Chemistry (1994) from Isabella Thoburn College, Lucknow.

She did her Ph.D. in Chemistry (1999) from Chaudhary Charan Singh University, Meerut and thesis executed under the doctoral advisor of Amiya Prasad Bhaduri[1] at Central Drug Research Institute, Lucknow

Career

Bhatnagar has been associated with research and development in the field of drug discovery and worked with various government and non-government organizations before her current assignment with Amity Institute of Biotechnology, Amity University, Noida as assistant director. She had joined Amity University as a lecturer around the time of its inception in 2005. Prior to that she had worked Project Associate in Department of Cell Biology, National Institute of Immunology, India. (07/01 to 04/04) and Project Associate in Department of Immunopharmacology at National Institute of Immunology, India. (05/00 to 05/01).Seema Bhatnagar started her career as Senior Research Fellow (Extended) in Medicinal Chemistry Division, associated with “Lactam Acetals in Organic Synthesis” under the supervision of Nitya Anand. Project fully sponsored by Council of Scientific and Industrial Research being executed at New Drug Discovery Research (NDDR), Ranbaxy Laboratories. (6/99-12/99)

Bhatnagar is currently working as Assistant Director at Amity Institute of Biotechnology[10] with Amity University, Noida. Bhatnagar has been associated with the University since its inception. She began her research career with project sponsored by the Department of Science and Technology (India) (DST).[11] She is currently pursuing project sponsored by Indian Council of Medical Research (ICMR),[12] along with her collaborator Bhudev Chandra Das.[13] Apart from this she has developed active collaboration with Bhyravabhotla Jayaram[14] at Indian Institute of Technology Delhi, Thankayyan Retnabai Santhosh Kumar[15] at Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram and Drug Discovery Unit at the University of Dundee to strengthen her research work. She has been the front runner at her Institute for being selected to attend Wellcome Trust Advanced Course in Small Molecule Drug Discovery. Prof Bhatnagar’s research credentials include several patents[16] granted & published by Intellectual property in India;[17] and publications[18] in Asian Journal of Pharmaceutical and Clinical Research,[19] Chemical Biology & Drug Design,[20] Annals of Oncology,[21] International Journal of ChemTech Research,[22] International Journal of Pharmacy and Pharmaceutical Sciences,[23] International Journal of Pharmaceutical Research & Allied Sciences,[24] Mycoses Ovid,[25] American Journal of Drug Discovery and Development,[26] Bioorganic & Medicinal Chemistry Letters,[27] An International Journal for Rapid Communication of Synthetic Organic Chemistry,[28] Contraception Journal,[29] Bioorganic & Medicinal Chemistry,[30] ChemInform,[31] Indian Journal of Chemistry.[32]

At Amity University along with the research, Prof.Bhatnagar also leads various initiatives, including collaboration of Foreign Universities and Scientific Research organizations, with Amity University, apart from Study Abroad Program and Three Continent Program. Prof.Bhatnagar has worked with the top research institutes and scientist in India during her Post Doc. including National Institute of Immunology, India Ranbaxy Laboratories, Central Drug Research Institute.

Professional Training's & Fellowship/Awards

  • Small Molecule Drug Discovery organized by Wellcome Trust at the Wellcome Trust Genome Campus, Cambridge UK.1st-6th June 2014

Fellowships/Awards

  • Awarded Senior Research Fellowship (Extended) by the Council of Scientific and Industrial Research, New Delhi. (06/99-12/99)
  • Nominated member of the Jury Panel (level 1) for the ‘Dupont India Challenge-2002 Science Paper Contest ‘(07/02)

Personal life

Bhatnagar was born in the city of Lucknow, Uttar Pradesh, India and is the eldest daughter of to Ram Chandra Srivastava (1940-1999), who was Associate Director with Defence Research and Development Organisation and Meera Srivastava. Her younger brother is heading IT Operations in a MNC, and a youngest sister is a physiotherapist currently living in Singapore.

Seema is married to an IT Consultant, and they together have one son and one daughter.

References

  1. 1 2 "Amiya P. Bhaduri's research works - Central Drug Research Institute, Lucknow (CDRI) and other places". ResearchGate. Archived from the original on 2018-10-06. Retrieved 2018-08-10.
  2. "Swati Kaushik profile at Research Gate". Archived from the original on 2018-10-06. Retrieved 2018-09-06.
  3. "Megha Rikhi profile at Research Gate". Archived from the original on 2018-10-06. Retrieved 2018-09-06.
  4. "Seminar Series: Dr. Seema Bhatnagar, "Neural circuitry underlying adaptations to repeated stress"". schulich.uwo.ca. Schulich:Medicine and Dentistry. Archived from the original on 2018-09-13. Retrieved 2018-10-05.
  5. "Seema Bhatnagar, Ph.D." med.upenn.edu. Perelman School of Medicine at the University of Pennsylvania. Archived from the original on 2018-10-06. Retrieved 2018-10-05.
  6. "Seema Bhatnagar - Publications". neurotree.org. Neurotree - The Neuroscience Academic Family Tree. Archived from the original on 2018-10-06. Retrieved 2018-10-05.
  7. "Seema Bhatnagar". researchgate.net. Research Gate.
  8. "Seema Bhatnagar". psychology.sas.upenn.edu. University of Pennsylvania - School of Arts and Sciences.
  9. "Seema Bhatnagar, PhD". chop.edu. The Children's Hospital of Philadelphia. Archived from the original on 2018-10-06. Retrieved 2018-10-05.
  10. "Professor Seema Bhatnagar's profile at Amity University, Noida" (PDF). Archived (PDF) from the original on 2018-10-06. Retrieved 2018-08-10.
  11. Department of Science and Technology (India)
  12. Indian Council of Medical Research
  13. "Dr.Bhudev C.Das's profile at Amity University" (PDF). Archived (PDF) from the original on 2018-10-06. Retrieved 2018-09-06.
  14. "Department of Chemistry @ IIT Delhi". chemistry.iitd.ac.in. Archived from the original on 2018-08-26. Retrieved 2018-09-06.
  15. "Rajiv Gandhi Centre for Biotechnology". rgcb.res.in. Archived from the original on 2018-10-05. Retrieved 2018-09-06.
  16. Ph.D, Seema BhatnagarAmity Institute of Biotechlogy · Amity University 16 32 ·. "Seema Bhatnagar - Ph.D (Chemistry) - Amity University". ResearchGate. Archived from the original on 2018-10-06. Retrieved 2018-08-10.
  17. Intellectual property in India
  18. Seema Bhatnagar's profile at Google Scholar
  19. "Seema Bhatnagar's Journal publication in Asian Journal of Pharmaceutical and Clinical Research". Archived from the original on 2018-10-05. Retrieved 2018-09-06.
  20. Seema Bhatnagar's Journal publication in Chemical Biology & Drug Design
  21. "Seema Bhatnagar's Journal publication in Annals of Oncology". Archived from the original on 2018-10-05. Retrieved 2018-08-10.
  22. "Seema Bhatnagar's Journal publication in International Journal of ChemTech Research". Archived from the original on 2018-04-05. Retrieved 2018-09-06.
  23. Seema Bhatnagar's Journal publications in International Journal of Pharmacy and Pharmaceutical Sciences Archived 2018-10-05 at the Wayback Machine. Archived 2018-10-05 at the Wayback Machine.
  24. "Seema Bhatnagar's Journal publications in International Journal of Pharmaceutical Research & Allied Sciences". Archived from the original on 2018-01-04. Retrieved 2018-09-06.
  25. "Seema Bhatnagar's Journal publication in Mycoses Ovid". Archived from the original on 2018-10-05. Retrieved 2018-09-06.
  26. "Seema Bhatnagar's Journal publication in American Journal of Drug Discovery and Development". Archived from the original on 2018-10-06. Retrieved 2018-08-21.
  27. Seema Bhatnagar's Journal publication in Bioorganic & Medicinal Chemistry Letters
  28. Seema Bhatnagar's Journal publication in An International Journal for Rapid Communication of Synthetic Organic Chemistry
  29. Seema Bhatnagar's Journal publication in Contraception Journal
  30. Seema Bhatnagar's Journal publication in Bioorganic & Medicinal Chemistry
  31. Seema Bhatnagar's Journal publication in ChemInform
  32. Seema Bhatnagar's Journal publication in Indian Journal of Chemistry

Patents Granted & Published

(*Retrieved 1-Sept-2018)
Granted by Intellectual property in India in 2017[1] 2010[2] 2004;[3] [4] [5] 2004[6]
Published by Intellectual property in India in 2016 [7] [8] [9] [10] 2014

[11]

[12] 2013

[13]

[14] [15] [16] [17] [18] 2012

[19]

[20] [21] 2010

[22]
  1. Patent No. 289169 Grant Date: 02/11/2017
    Patent Appl. No.:(674/DEL/2009) Filing Date: 31/03/2009
    Title: A process for the synthesis of E-3- halo-2- styryl/vinyl chromones as therapeutic agents Inventors: Seema Bhatnagar, Swati Kaushik
  2. Patent No. 292375 Grant Date:: 4/2010
    Patent Appl. No.:(538/DEL/2009), Filing Date: 20/03/2009
    Title: A process for the synthesis of Z-3- halo-2- styryl/vinyl chromones as therapeutic agents Inventors: Seema Bhatnagar, Swati Kaushik
  3. Patent No.: 191519 Grant Date: 30/06/04
    Patent Appl. No.: 2716/DEL/1998 Filing Date 11/09/98
    Title: A PROCESS FOR THE PREPARATION OF 1-ARYL-6- HALO-3-HYDROXY-HEX-2-ENE-1-ONE
    Inventors: Seema Srivastava, Sanjay Batra, Amiya Prasad Bhaduri, Nidhi Srivastava, Arti Shukla et al
  4. Patent No.: 191084 Grant Date: 12/04/04
    Patent Appl. No.: 2715/DEL/1998 Filing Date 11/09/98
    Title: A process for the preparation of 1-aryl-3-aminoalkyl(N,N-disubstituted aminohex-2-ene-1-ones-6-hydroxy useful as therapeutic agents
    Inventors: Seema Srivastava, Sanjay Batra, Amiya Prasad Bhaduri, Nidhi Srivastava, Arti Shukla et al
  5. Patent No.: 190789 Grant Date: 15/03/04
    Patent Appl. No.: 2714/DEL/1998 Filing Date 11/09/98
    Title: A process for the preparation of 1-substituted-aminohex-2-ene-1-one-6-hydroxy useful as therapeutic agents
    Inventors: Seema Srivastava, Sanjay Batra, Amiya Prasad Bhaduri, Nidhi Srivastava, Arti Shukla et al'
  6. Patent No.: 190787 Grant Date: 16/03/04 Patent Appl. No.: 2711/DEL/1998 Filing Date 11/09/98
    Title: A process for the simultaneous preparation of 3-(2-morpholin-4-yl) ethyl amino-1-aryl -hex-2-ene-1-one-6 hydroxy and 2-(1-(2-morpholin-4-yl) ethyl)- pyrrolidin -2-yl) -1- aryl -1-oxo-ethylidene useful as therapeutic Agents Inventors: Seema Srivastava, Sanjay Batra, Amiya Prasad Bhaduri, Nidhi Srivastava, Arti Shukla et al
  7. Publication Date: 09/12/2016
    Patent Appl. No.:(1673/DEL/2015) Filing Date: 05/06/2015
    Title: Biphenyl analogs and their derivatives as antifungal agents Inventors: Megha Rikhi, Shanu Hooda, Swati Kushik, Seema Bhatnagar, Pooja Vijayaraghavan, Anjali Soni, B Jayaram
  8. Publication Date: 28/10/2016
    Patent Appl. No.:(1112/DEL/2015) Filing Date: 22/04/2015
    Title: A NOVEL BIOCONJUGATE DRUG FOR TARGETED TREATMENT OF CANCER AND CANCER STEM CELLS Inventors: Bhudev C Das, Seema Bhatnagar
  9. Publication Date: 14/10/2016
    Patent Appl. No.:(979/DEL/2015) Filing Date: 07/04/2015
    Title: A METHOD FOR THE SYNTHESIS OF 3-AMINOALKYL-2-STYRYL CHROMONE DERIVATIVES FOR ANTICANCER AND ANTIOXIDANT ACTIVITY Inventors: Swati Kushik, Megha Rikhi, Seema Bhatnagar
  10. Publication Date: 14/10/2016
    Patent Appl. No.:(978/DEL/2015) Filing Date: 07/04/2015
    Title: ISOXAZOYL STYRYLCHROMONES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS Inventors: Swati Kushik, Megha Rikhi, Seema Bhatnagar
  11. Publication Date: 15/08/2014
    Patent Appl. No.:(3595/DEL/2012) Filing Date: 23/11/2012
    Title: A METHANOLIC EXTRACT OF LICHEN PARMELIA AS POTENT ANTI- HELICOBACTER PYLORI AGENT Inventors: Rajashree Das, Pooja Vijayaraghavan, Hina Sanwal, Shweta Mahant, Seema Bhatnagar
  12. Publication Date: 15/08/2014
    Patent Appl. No.:(3126/DEL/2012) Filing Date: 08/10/2012
    Title: 1,3-DIACETYL BIPHENYL ANALOGS, THEIR DERIVATIVES AND SALTS THEREOF AS ANTICANCER AGENTS. Inventors: Seema Bhatnagar, B. Jayaram, Megha Rikhi, Anjali Soni, Swati Kaushik
  13. Publication Date: 12/04/2013
    Patent Appl. No.:(2909/DEL/2011) Filing Date: 10/10/2011
    Title: A novel bioactive extract for prevention/ treatment of acne Inventors: Megha Rikhi, Swati Kaushik, Pooja Vijayaraghavan, Hina Sanwal, Seema Bhatnagar, Ashwani K Srivastava
  14. Publication Date: 22/03/2013
    Patent Appl. No.:(2740/DEL/2011) Filing Date: 21/09/2011
    Title: A METHOD FOR THE PREPARATION OF DISINFECTANT, AIR PURIFIER AND HAND SANITIZER USING COMBINATION OF PLANT EXTRACTS Inventors: Pooja Vijayaraghavan, Hina Sanwal, Megha Rikhi, Swati Kaushik, Seema Bhatnagar, Ashwani K Srivastava
  15. Publication Date: 08/03/2013
    Patent Appl. No.:(2590/DEL/2011) Filing Date: 08/09/2011
    Title: HERBAL FORMULATION EFFECTIVE AGAINST ACNE VULGARIS Inventors: Pooja Vijayaraghavan, Seema Bhatnagar, Ashwani K Srivastava
  16. Publication Date: 01/03/2013
    Patent Appl. No.:(2473/DEL/2011) Filing Date: 30/08/2011
    Title: NOVEL BIOACTIVE EXTRACT OF ORANGE PEEL EXHIBITING BACTERICIDAL/BACTERIOSTATIC ACTIVITY AGAINST MICROCOCCUS SPECIES Inventors: Swati Kaushik, Megha Rikhi, Seema Bhatnagar, Pooja Vijayaraghavan, Ashwani K Srivastava
  17. Publication Date: 11/10/2013
    Patent Appl. No.:(2472/DEL/2011) Filing Date: 30/08/2011
    Title: NOVEL BIOACTIVE EXTRACT OF RATANJOT TO INHIBIT/DECREASE THE MELANIN PRODUCTION IN MELANOCYTES Inventors: Pooja Vijayaraghavan, Seema Bhatnagar, Aswani Srivastava
  18. Publication Date: 01/03/2013
    Patent Appl. No.:(2471/DEL/2011) Filing Date: 30/08/2011
    Title: NOVEL COMPOSITION OF NATURAL EXTRACTS AS DISINFECTANT, AIR PURIFIER AND HAND SANITIZER Inventors: Pooja Vijayaraghavan, Seema Bhatnagar, Ashwani K Srivastava, Swati Kaushik, Megha Rikhi
  19. Publication Date: 14/12/2012
    Patent Appl. No.:(1627/DEL/2011) Filing Date: 09/06/2011
    Title: NOVEL EFFECT OF SPICES ON DEMELANIZATION OF PATHOGENIC FUNGUS Inventors: Seema Bhatnagar, Hina Sanwal, Pooja Vijayaraghavan, Ashwani K Srivastava
  20. Publication Date: 14/12/2012
    Patent Appl. No.:(1626/DEL/2011) Filing Date: 09/06/2011
    Title: NOVEL EFFECT OF CITRUS PLANT AS ANTIFUNGAL LEADING TO REDUCED PATHOGENICITY Inventors: Swati Kaushik, Hina Sanwal, Pooja Vijayaraghavan, Ashwani K Srivastava, Seema Bhatnagar
  21. Publication Date: 14/12/2012
    Patent Appl. No.:(1625/DEL/2011) Filing Date: 09/06/2011
    Title: NOVEL EFFECT OF MEDICINAL PLANT AS ANTIFUNGALS LEADING TO REDUCED PATHOGENICITY Inventors: Ashwani K Srivastava, Megha Rikhi, Seema Bhatnagar, Hina Sanwal, Pooja Vijayaraghavan
  22. Publication Date: 09/11/2010
    Patent Appl. No.:(993/DEL/2009) Filing Date: 15/05/2009
    Title: STYRYL CHROMONES AS SELECTIVE ESTROGEN RECEPTOR MODULATOR Inventors: Seema Bhatnagar, Swati Kaushik, Shakti Sahi

Publications

Post-Doctorate 2018;[1] 2017;[2] 2016;[3] 2015[4]

[5]

2014;[6] 2012[7] [8] [9] 2010[10] [11]

Pre-Doctorate 2001;[12] 1999;[13] 1997[14] 1996[15]

References

  1. Mahant, Shweta; Gehlot, Valentina; Bhatnagar, Seema; Rikhi, Megha; Mukhopadhyay, Asish Kumar; Dutta, Sangitanjan; Agarwal, Anil; Das, Kunal; Das, Rajashree (August 2018). "Antibiogram profiling of Helicobacter Pylori strains and the efficacy of Brassica Capitata against resistant strains isolated from the patients suffering from gastroduodenal diseases in Guwahati, Assam". Asian Journal of Pharmaceutical and Clinical Research. 11 (8): 176–180. doi:10.22159/ajpcr.2018.v11i8.25220. ISSN 2455-3891.
  2. Bhatnagar, Seema; Soni, Anjali; Kaushik, Swati; Rikhi, Megha; Santhoshkumar, Thankayyan Retnabai; Jayaram, Bhyravabhotla (20 October 2017). "Nonsteroidal estrogen receptor isoform‐selective biphenyls". Chemical Biology & Drug Design. 91 (2): 620–630. doi:10.1111/cbdd.13126. PMID 29052968.
  3. Kaushik, Swati; Rikki, Megha; Kumar, T.R.S.; Bhatnagar, Seema (1 December 2016). "162P Novel isoxazolyl chromones antagonizing ERα induces anticancer activity via triggering caspase-3 activation". Annals of Oncology. 27 (9). doi:10.1093/annonc/mdw579.014.
  4. Rikhi, Megha; Bharadwaj, Dinesh Kumar; Bhatnagar, Seema (2015). "In Vitro Antioxidant Activity of Biphenyl-2, 6-diethanone Derivatives" (PDF). International Journal of ChemTech Research. 8 (12): 552–558. ISSN 0974-4290.
  5. Kaushik, Swati; Rikhi, Megha; Bhatnagar, Seema* (27 October 2015). "Docking and cytotoxicity studies of 2-vinylchromone derivatives on human breast cancer cell lines". International Journal of Pharmacy and Pharmaceutical Sciences. 7 (12): 113–117. ISSN 0975-1491. Archived from the original on 2018-10-05. Retrieved 2018-09-05.
  6. Rikhi, Megha; Bhatnagar, Seema; Sanwal, Hina; Vijayaraghavan, Pooja (1 April 2015). "Antimicrobial Properties of Indian Medicinal Plants and Their Effect in Attenuating Fungal Virulence: A Herbal Approach". International Journal of Pharmaceutical Research & Allied Sciences. 4 (2): 101–111.
  7. Vijayaraghavan, Pooja; Sanwal, Hina; Goyal, A; Srivastava, Ashwani K (2012). "Activity of Myristica fragrans and its effect against filamentous and non-filamentous fungus" (PDF). International Journal of Pharmacy and Pharmaceutical Sciences. 4 (1): 538–540. ISSN 0975-1491. Archived (PDF) from the original on 2018-10-06. Retrieved 2018-08-21.
  8. Vijayaraghavan, Pooja; Bhatnagar, Seema; Sanwal, Heena (1 June 2012). "Efficacy of natural extracts against: P101Candida albicans: P101biofilms: P101". Mycoses Ovid. 55 (127). ISSN 0933-7407.
  9. Vijayaraghavan, Pooja; Sanwal, Hina; Bhatnagar, Seema; Srivastava, Ashwani K (2012). "Targeting virulence: novel effect of Myristica fragrans on melanisation and conidiation of Aspergillus niger". American Journal of Drug Discovery and Development. 2 (1): 32–39. doi:10.3923/ajdd.2012.32.39.
  10. Bhatnagar, Seema; Shai, Shakti; Kachar, Puneet; Kaushik, Swati; Dave, Manan K.; Shukla, Akshara; Goel, Ashita (15 August 2010). "Synthesis and docking studies on styryl chromones exhibiting cytotoxicity in human breast cancer cell line". Bioorganic & Medicinal Chemistry Letters. 20 (16): 4945–4950. doi:10.1016/j.bmcl.2010.05.108. PMID 20621472.
  11. Bhatnagar, Seema; Kaushik, Swati; Sahi, Shakti (15 Dec 2010). "Stereoselective Bromination of 2-Vinyl Chromones Using NBS". An International Journal for Rapid Communication of Synthetic Organic Chemistry. 41, 2010 (2): 219–226. doi:10.1080/00397910903534007.
  12. Mehrotra, Purshottam Kishore; Kitchlu, Shakti; Batra, Sanjay; Srivastava, Seema; Bhaduri, Amiya Prasad (September 2001). "Search for new chemical entities as menses inducing agents". Contraception. 64 (3): 187–191. doi:10.1016/S0010-7824(01)00244-X.
  13. Srivastava, Seema; Bajpai, Lakshmi Kant; Batra, Sanjay; Bhaduri, Amiya Prasad; Maikhuri, J.P.; Gupta, Gopal; Dhar, J.D. (November 1999). "In search of new chemical entities with spermicidal and anti-HIV activities". Bioorganic & Medicinal Chemistry. 7 (11): 2607–2613. doi:10.1016/S0968-0896(99)00188-1.
  14. Srivastava, Seema; Batra, Sanjay; Roy, R; Bhaduri, Amiya Prasad (30 September 1997). "Reactions of Cyclohexanone with Arylidene Malononitriles: A Reinvestigation". ChemInform. 28 (40): no. doi:10.1002/chin.199740067.
  15. Batra, Sanjay; Bhaduri, Amiya Prasad; Srivastava, Seema (1996). "A facile acid catalyzed ring .transformation of 4H-pyrans to 1,2,3,4-tetrahydropyridin-2-ones and 3,4 dihydronaphtho [1,2-b]-pyran-2[H]-ones.". Indian Journal of Chemistry: 602–604.
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