Sca-1

Sca-1 stands for "Stem cells antigen-1". It consist of 18-kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein (GPI-AP) of the LY6 gene family.[1] It is the common biological marker used to identify hematopoitic stem cell (HSC) along with other markers.

Application of Sca-1

  1. Sca-1 has a regenerative role in cardiac repair: Endogenous Sca-1+CD31− cells upon myocardial infarction as well as Sca-1 protein.[2]
  2. Sca-1 plays a role in hematopoietic progenitor/stem cell lineage fate and c-kit expression.[3]

References

  1. ↑ "Concise Review: Stem Cell Antigen-1: Expression, Function, and Enigma".
  2. ↑ Wang, X; Hu, Q; Nakamura, Y; Lee, J; Zhang, G; From, AH; Zhang, J. "The role of the sca-1+/CD31- cardiac progenitor cell population in postinfarction left ventricular remodeling". Stem Cells. 24: 1779–1788. doi:10.1634/stemcells.2005-0386. PMID 16614004.
  3. ↑ Bradfute, SB; Graubert, TA; Goodell, MA (2005). "Roles of Sca-1 in hematopoietic stem/progenitor cell function". Exp. Hematol. 33: 836–43. doi:10.1016/j.exphem.2005.04.001. PMID 15963860.


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