Sarah E Reisman

Sarah E Reisman is a Professor of Chemistry at the California Institute of Technology and winner of the Arthur C Cope Scholar Award and Tetrahedron Young Investigator Award for Organic Synthesis.[1] Reisman's research focuses on the total synthesis of complex natural products. Her group's key accomplishments include the streamlined total synthesis of (+)-ryanodol, and the first total synthesis of (–)-acetylaranotin.

Early career and education

Undergraduate Studies

Reisman received a BA in Chemistry from Connecticut College in 2001 and conducted research in the lab of Timo V Ovaska on the synthesis of tetracyclic natural products, including phorbol.[2][3]

Graduate Studies

Reisman obtained her PhD from Yale University in 2006, working in the lab of John Wood on the total synthesis of (±)-Welwitindolinone A Isonitrile.[4]

Postdoctoral Studies

From 2006-2008 Reisman was an NIH postdoctoral fellow in the lab of Eric N Jacobsen at Harvard University and worked with Abigail Doyle to develop an enantioselective substitution of silyl ketenes onto an alkoxy chloride via an oxacarbenium ion, using a novel thiourea organocatalyst. The paper describing their discovery has been cited over 230 times.[5]

Research

Sarah Reisman began her independent career as an Assistant Professor of Chemistry at Caltech in 2008 and was directly promoted to Full Professor in 2014.

The Reisman lab focuses on the synthesis of natural products and development of new chemical reactions. They were the first research group to complete the total syntheses of (–)-acetylaranotin (40 years after the natural product was first isolated),[6][7] (–)-Maoecrystal Z,[8] and the first enantioselective total syntheses of (–)-8-Demethoxyrunanine and (–)-Cepharatines A, C and D.[9] Their total synthesis of (+)-ryanodol was completed in 15 synthetic steps,[10] a significant improvement on the previous shortest synthetic route of 35 steps developed by Masayuki Inoue of the University of Tokyo.[11][12] Some of their other completed total syntheses include natural products (+)-Naseseazines A and B,[13] (+)-Salvileucalin B[14][15] and (+)-Psiguadial B[16][17][18]

Awards and Honours

Reisman was awarded the Boehringer Ingelheim New Faculty Grant,[19] the Alfred P Sloan Foundation Fellowship[20] and a 5-year NSF CAREER Award in 2011.[21] She was the winner of the Novartis Early Career Award[22] and the Cottrell Scholar Award in 2012.[23] She received the Arthur C. Cope Scholar Award from the American Chemical Society in 2013[24][25] and the Tetrahdron Young Investigator Award for Organic Synthesis in 2014.[26] Reisman was one of the ten inaugural American Chemical Society WCC's Rising Star Award winners, chosen “for excellence in the development of catalytic asymmetric methodologies for natural product synthesis.”[27][28] In 2015 Reisman was identified in a survey of 30 Nobel Prize winners as one of ten "early-career scientists on their way to critical acclaim".[29]

References

  1. ↑ "The Reisman Group". reismangroup.caltech.edu. Retrieved 2018-07-26.
  2. ↑ "Ovaska Research Group". Connecticut College. Retrieved 2018-07-26.
  3. ↑ "Bright Young Minds: Meet 10 scientists who are making their mark". Science News. 188 (7): 20–26. 2015-09-23. doi:10.1002/scin.2015.188007018. ISSN 0036-8423.
  4. ↑ Reisman, Sarah E.; Ready, Joseph M.; Weiss, Matthew M.; Hasuoka, Atsushi; Hirata, Makoto; Tamaki, Kazuhiko; Ovaska, Timo V.; Smith, Catherine J.; Wood, John L. (February 2008). "Evolution of a Synthetic Strategy:  Total Synthesis of (±)-Welwitindolinone A Isonitrile". Journal of the American Chemical Society. 130 (6): 2087–2100. doi:10.1021/ja076663z. ISSN 0002-7863. PMID 18198870.
  5. ↑ Reisman, Sarah E.; Doyle, Abigail G.; Jacobsen, Eric N. (June 2008). "Enantioselective Thiourea-Catalyzed Additions to Oxocarbenium Ions". Journal of the American Chemical Society. 130 (23): 7198–7199. doi:10.1021/ja801514m. ISSN 0002-7863. PMC 2574628. PMID 18479086.
  6. ↑ Codelli, Julian A.; Puchlopek, Angela L. A.; Reisman, Sarah E. (2011-10-28). "Enantioselective Total Synthesis of (−)-Acetylaranotin, a Dihydrooxepine Epidithiodiketopiperazine". Journal of the American Chemical Society. 134 (4): 1930–1933. doi:10.1021/ja209354e. ISSN 0002-7863. PMC 3271125. PMID 22023250.
  7. ↑ Drahl, Carmen. "Alkaloid Acetylaranotin Made After 40-Year Quest | Chemical & Engineering News". cen.acs.org. Retrieved 2018-07-29.
  8. ↑ Cha, J. Y.; Yeoman, J. T. S.; Reisman, S. E. (2011-11-18). "Synthesis of (-)-Maoecrystal Z". Synfacts. 2011 (12): 1271. doi:10.1055/s-0031-1289337. ISSN 1861-1958.
  9. ↑ Ley, Steven V.; Frost, James R. (2011-12-19). "Synthesis of (–)-8-Demethoxyrunanine and (–)-Cepharatines A, C and D". Synfacts. 8 (1): 0014. doi:10.1055/s-0031-1289924. ISSN 1861-1958.
  10. ↑ Chuang, Kangway V.; Xu, Chen; Reisman, Sarah E. (2016-08-26). "A 15-step synthesis of (+)-ryanodol". Science. 353 (6302): 912–915. doi:10.1126/science.aag1028. ISSN 0036-8075. PMC 5505075. PMID 27563092.
  11. ↑ Lemonick, Sam. "A Simpler Way To Make A Complicated Molecule". Forbes. Retrieved 2018-07-26.
  12. ↑ Pei-Qiang., Huang, (2016). Efficiency in natural products total synthesis. [Place of publication not identified]: John Wiley & Sons. p. 132. ISBN 9781118940204. OCLC 1046102804.
  13. ↑ Kieffer, Madeleine E.; Chuang, Kangway V.; Reisman, Sarah E. (2013-04-03). "Copper-Catalyzed Diastereoselective Arylation of Tryptophan Derivatives: Total Synthesis of (+)-Naseseazines A and B". Journal of the American Chemical Society. 135 (15): 5557–5560. doi:10.1021/ja4023557. ISSN 0002-7863. PMC 3662218. PMID 23540731.
  14. ↑ Levin, S.; Nani, R. R.; Reisman, S. E. (2011-05-19). "Enantioselective Synthesis of (+)-Salvileucalin B". Synfacts. 2011 (6): 0590. doi:10.1055/s-0030-1260369. ISSN 1861-1958.
  15. ↑ "Column: Totally Synthetic". Chemistry World. Retrieved 2018-07-29.
  16. ↑ Chapman, Lauren M.; Beck, Jordan C.; Wu, Linglin; Reisman, Sarah E. (2016-08-02). "Enantioselective Total Synthesis of (+)-Psiguadial B". Journal of the American Chemical Society. 138 (31): 9803–9806. doi:10.1021/jacs.6b07229. ISSN 0002-7863. PMID 27452034.
  17. ↑ Halford, Bethany. "An enantioselective synthesis of (+)-psiguadial B | Chemical & Engineering News". cen.acs.org. Retrieved 2018-07-29.
  18. ↑ Carreira, Erick M.; Nannini, Leonardo J. (2016-09-19). "Synthesis of (+)-Psiguadial B". Synfacts. 12 (10): 1003. doi:10.1055/s-0036-1589189. ISSN 1861-1958.
  19. ↑ "Boehringer Ingelheim New Investigator Award in organischer Chemie: A. G. Doyle / Boehringer Ingelheim New Faculty Grant: S. E. Reisman / GDCh-Preis für Schriftsteller und Journalisten: V. Köster". Angewandte Chemie. 124 (11): 2591. 2012-02-28. doi:10.1002/ange.201201128. ISSN 0044-8249.
  20. ↑ "Past Fellows". sloan.org. Retrieved 2018-07-29.
  21. ↑ "NSF Award Search: Award#1057143 - CAREER: New Strategies and Methods for the Total Synthesis of Propellane Natural Products". www.nsf.gov. Retrieved 2018-07-29.
  22. ↑ "Novartis Early Career Award in Organic Chemistry 2012 :: News :: ChemistryViews". www.chemistryviews.org. Retrieved 2018-07-29.
  23. ↑ "Sarah Reisman, Cottrell Scholar Award - Research Corporation for Science Advancement". Research Corporation for Science Advancement. Retrieved 2018-07-31.
  24. ↑ Drahl, Carmen. "Arthur C. Cope Scholar: Sarah E. Reisman | Chemical & Engineering News". cen.acs.org. Retrieved 2018-07-26.
  25. ↑ "Arthur C. Cope Scholar Awards - American Chemical Society". American Chemical Society. Retrieved 2018-07-29.
  26. ↑ Tetrahedron Young Investigator Award.
  27. ↑ "Pasadena Now " Society Names Caltech Chemist Sarah Reisman a Rising Star | Pasadena California, Hotels,CA Real Estate,Restaurants,City Guide... - Pasadena.com". www.pasadenanow.com. Retrieved 2018-07-29.
  28. ↑ "Women Chemists Committee announces inaugural Rising Star Award and winners - American Chemical Society". American Chemical Society. Retrieved 2018-07-29.
  29. ↑ "Bright Young Minds: Meet 10 scientists who are making their mark". Science News. 188 (7): 20–26. 2015-09-23. doi:10.1002/scin.2015.188007018. ISSN 0036-8423.
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