SYNJ2BP

SYNJ2BP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ENO, 2JIK, 2JIN
Identifiers
Aliases	SYNJ2BP, ARIP2, OMP25, synaptojanin 2 binding protein
External IDs	MGI: 1344347 HomoloGene: 10161 GeneCards: SYNJ2BP
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	70,417,061 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	81,532,911 bp[2]
Gene ontology
Molecular function	• protein binding; • protein C-terminus binding; • ionotropic glutamate receptor binding;
Cellular component	• integral component of membrane; • mitochondrial outer membrane; • membrane; • mitochondrion; • integral component of mitochondrial outer membrane; • ionotropic glutamate receptor complex; • basolateral plasma membrane; • cell junction; • neuromuscular junction; • neuron projection; • postsynaptic density membrane;
Biological process	• negative regulation of endothelial cell migration; • negative regulation of angiogenesis; • regulation of Notch signaling pathway; • negative regulation of endothelial cell proliferation; • negative regulation of sprouting angiogenesis; • negative regulation of ERK1 and ERK2 cascade; • protein targeting; • Rho protein signal transduction; • regulation of endocytosis; • intracellular distribution of mitochondria; • chemical synaptic transmission; • receptor clustering; • establishment or maintenance of epithelial cell apical/basal polarity; • receptor localization to synapse; • cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	55333
	24071
	ENSG00000213463
	ENSMUSG00000090935
	P57105
	Q9D6K5
	NM_018373
	NM_025292; NM_001309814
	NP_060843
	NP_001296776; NP_001296777
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptojanin-2-binding protein is a protein that in humans is encoded by the SYNJ2BP gene.^[5]^[6]

Interactions

SYNJ2BP has been shown to interact with:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000213463 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090935 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 3 Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". The Journal of Biological Chemistry. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.
↑ "Entrez Gene: SYNJ2BP synaptojanin 2 binding protein".
↑ Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561.
1 2 Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.

Nemoto Y, De Camilli P (Jun 1999). "Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein". The EMBO Journal. 18 (11): 2991–3006. doi:10.1093/emboj/18.11.2991. PMC 1171381. PMID 10357812.
Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
Weins A, Schwarz K, Faul C, Barisoni L, Linke WA, Mundel P (Oct 2001). "Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein". The Journal of Cell Biology. 155 (3): 393–404. doi:10.1083/jcb.200012039. PMC 2150840. PMID 11673475.
Lin F, Yu YP, Woods J, Cieply K, Gooding B, Finkelstein P, Dhir R, Krill D, Becich MJ, Michalopoulos G, Finkelstein S, Luo JH (Nov 2001). "Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers". The American Journal of Pathology. 159 (5): 1603–12. doi:10.1016/S0002-9440(10)63006-4. PMC 3277320. PMID 11696420.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000213463 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090935 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid11882656-5] 1 2 3 Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". The Journal of Biological Chemistry. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.

[entrez-6] "Entrez Gene: SYNJ2BP synaptojanin 2 binding protein".

[pmid15451561-7] Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (Oct 2004). "Novel factors in regulation of activin signaling". Molecular and Cellular Endocrinology. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561.

[pmid10827173-8] 1 2 Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (Aug 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.

SYNJ2BP

Interactions

References

Further reading