STT3B

STT3B
Identifiers
Aliases	STT3B, CDG1X, SIMP, STT3-B, catalytic subunit of the oligosaccharyltransferase complex
External IDs	MGI: 1915542 HomoloGene: 7387 GeneCards: STT3B
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	31,637,622 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	115,310,421 bp[2]
Gene ontology
Molecular function	• transferase activity; • oligosaccharyl transferase activity; • dolichyl-diphosphooligosaccharide-protein glycotransferase activity; • transferase activity, transferring glycosyl groups; • metal ion binding;
Cellular component	• integral component of membrane; • oligosaccharyltransferase complex; • endoplasmic reticulum; • membrane; • endoplasmic reticulum membrane;
Biological process	• post-translational protein modification; • protein glycosylation; • co-translational protein modification; • response to unfolded protein; • protein N-linked glycosylation via asparagine; • ubiquitin-dependent ERAD pathway; • glycoprotein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	201595
	68292
	ENSG00000163527
	ENSMUSG00000032437
	Q8TCJ2
	Q3TDQ1
	NM_178862
	NM_024222
	NP_849193
	NP_077184
	Wikidata
View/Edit Human	View/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit STT3B is an enzyme that in humans is encoded by the STT3B gene.^[5]^[6]^[7]

Function

The SIMP protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Like ITM1 (MIM 601134), SIMP is homologous to yeast STT3, an oligosaccharyltransferase essential for cell proliferation (McBride et al., 2002).[supplied by OMIM]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163527 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032437 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (July 2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Molecular Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
↑ McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, Bergeron J, Perreault C (November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619.
1 2 "Entrez Gene: STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)".

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Shibatani T, David LL, McCormack AL, Frueh K, Skach WR (April 2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163527 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032437 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid12887896-5] Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (July 2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Molecular Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.

[pmid12439619-6] McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, Bergeron J, Perreault C (November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619.

[entrez-7] 1 2 "Entrez Gene: STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)".

STT3B

Function

See also

References

Further reading