STH (gene)

STH
Identifiers
AliasesSTH, MAPTIT, saitohin
External IDsHomoloGene: 88448 GeneCards: STH
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.31Start45,999,250 bp[1]
End45,999,694 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

246744

n/a

Ensembl

ENSG00000256762
ENSG00000281139

n/a

UniProt

Q8IWL8

n/a

RefSeq (mRNA)

NM_001007532

n/a

RefSeq (protein)

NP_001007533

n/a

Location (UCSC)Chr 17: 46 – 46 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Saitohin is a protein that in humans is encoded by the STH gene.[3][4][5]

References

  1. 1 2 3 ENSG00000281139 GRCh38: Ensembl release 89: ENSG00000256762, ENSG00000281139 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Conrad C, Vianna C, Freeman M, Davies P (May 2002). "A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease". Proc Natl Acad Sci U S A. 99 (11): 7751–6. doi:10.1073/pnas.112194599. PMC 124341. PMID 12032355.
  4. ↑ Gao L, Tse SW, Conrad C, Andreadis A (Nov 2005). "Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6". J Biol Chem. 280 (47): 39268–72. doi:10.1074/jbc.M506116200. PMID 16186110.
  5. ↑ "Entrez Gene: STH saitohin".

Further reading

  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
  • Cook L, Brayne CE, Easton D, et al. (2002). "No evidence for an association between Saitohin Q7R polymorphism and Alzheimer's disease". Ann. Neurol. 52 (5): 690–1. doi:10.1002/ana.10362. PMID 12402275.
  • Verpillat P, Ricard S, Hannequin D, et al. (2002). "Is the saitohin gene involved in neurodegenerative diseases?". Ann. Neurol. 52 (6): 829–32. doi:10.1002/ana.10384. PMID 12447938.
  • Zekanowski C, Pepłońska B, Styczyńska M, et al. (2003). "Mutation screening of the MAPT and STH genes in Polish patients with clinically diagnosed frontotemporal dementia". Dementia and Geriatric Cognitive Disorders. 16 (3): 126–31. doi:10.1159/000070999. PMID 12826737.
  • Combarros O, Rodero L, Infante J, et al. (2003). "Age-dependent association between the Q7R polymorphism in the Saitohin gene and sporadic Alzheimer's disease". Dementia and Geriatric Cognitive Disorders. 16 (3): 132–5. doi:10.1159/000071000. PMID 12826738.
  • de Silva R, Hope A, Pittman A, et al. (2004). "Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy". Neurology. 61 (3): 407–9. doi:10.1212/01.wnl.0000073140.25533.90. PMID 12913211.
  • Pepłońska B, Zekanowski C, Religa D, et al. (2003). "Strong association between Saitohin gene polymorphism and tau haplotype in the Polish population". Neurosci. Lett. 348 (3): 163–6. doi:10.1016/S0304-3940(03)00788-2. PMID 12932819.
  • Johansson A, Zetterberg H, Håkansson A, et al. (2006). "TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease". Neuro-Degenerative Diseases. 2 (1): 28–35. doi:10.1159/000086428. PMID 16909000.


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