STAU2

STAU2
Identifiers
AliasesSTAU2, 39K2, 39K3, staufen double-stranded RNA binding protein 2
External IDsMGI: 1352508 HomoloGene: 8666 GeneCards: STAU2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q21.11Start73,420,369 bp[1]
End73,747,708 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

27067

29819

Ensembl

ENSG00000040341

ENSMUSG00000025920

UniProt

Q9NUL3

Q8CJ67

RefSeq (mRNA)

NM_001111272
NM_025303
NM_001347044
NM_001347045

RefSeq (protein)

NP_001104742
NP_001333973
NP_001333974
NP_079579

Location (UCSC)Chr 8: 73.42 – 73.75 MbChr 1: 16.23 – 16.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene.[5][6]

Function

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000040341 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025920 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (November 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.
  6. 1 2 "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".

Further reading

  • Kiebler MA, DesGroseillers L (January 2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron. 25 (1): 19–28. doi:10.1016/S0896-6273(00)80868-5. PMID 10707969.
  • Furic L, Maher-Laporte M, DesGroseillers L (February 2008). "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes". Rna. 14 (2): 324–35. doi:10.1261/rna.720308. PMC 2212254. PMID 18094122.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
  • Chatel-Chaix L, Clément JF, Martel C, Bériault V, Gatignol A, DesGroseillers L, Mouland AJ (April 2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles". Molecular and Cellular Biology. 24 (7): 2637–48. doi:10.1128/MCB.24.7.2637-2648.2004. PMC 371130. PMID 15024055.
  • Duchaîne TF, Hemraj I, Furic L, Deitinghoff A, Kiebler MA, DesGroseillers L (August 2002). "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles". Journal of Cell Science. 115 (Pt 16): 3285–95. PMID 12140260.
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