STAG1

STAG1
Identifiers
AliasesSTAG1, SA1, SCC3A, stromal antigen 1, MRD47
External IDsMGI: 1098658 HomoloGene: 21191 GeneCards: STAG1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q22.3Start136,336,233 bp[1]
End136,752,403 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10274

20842

Ensembl

ENSG00000118007

ENSMUSG00000037286

UniProt

Q8WVM7

Q9D3E6

RefSeq (mRNA)

NM_005862

NM_009282
NM_001357264
NM_001357265

RefSeq (protein)

NP_005853

NP_033308
NP_001344193
NP_001344194

Location (UCSC)Chr 3: 136.34 – 136.75 MbChr 9: 100.6 – 100.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cohesin subunit SA-1 is a protein that in humans is encoded by the STAG1 gene.[5][6]

Function

This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase.[6]

Interactions

STAG1 has been shown to interact with STAG2.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000118007 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037286 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
  6. 1 2 "Entrez Gene: STAG1 stromal antigen 1".
  7. ↑ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Losada A, Yokochi T, Hirano T (May 2005). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". Journal of Cell Science. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.
  • Anazawa Y, Arakawa H, Nakagawa H, Nakamura Y (October 2004). "Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway". Oncogene. 23 (46): 7621–7. doi:10.1038/sj.onc.1207270. PMID 15361841.
  • Prieto I, Pezzi N, Buesa JM, Kremer L, Barthelemy I, Carreiro C, Roncal F, Martinez A, Gomez L, Fernandez R, Martinez-A C, Barbero JL (June 2002). "STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis". EMBO Reports. 3 (6): 543–50. doi:10.1093/embo-reports/kvf108. PMC 1084142. PMID 12034751.
  • Gregson HC, Schmiesing JA, Kim JS, Kobayashi T, Zhou S, Yokomori K (December 2001). "A potential role for human cohesin in mitotic spindle aster assembly". The Journal of Biological Chemistry. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136.
  • Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.