SSR1

SSR1
Identifiers
AliasesSSR1, TRAPA, signal sequence receptor subunit 1
External IDsMGI: 105082 HomoloGene: 2368 GeneCards: SSR1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p24.3Start7,268,306 bp[1]
End7,347,446 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6745

107513

Ensembl

ENSG00000124783

ENSMUSG00000021427

UniProt

P43307

Q9CY50

RefSeq (mRNA)

NM_001292008
NM_003144

NM_025965
NM_001360842

RefSeq (protein)

NP_001278937
NP_003135

NP_080241
NP_001347771

Location (UCSC)Chr 6: 7.27 – 7.35 MbChr 13: 37.97 – 37.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Translocon-associated protein subunit alpha is a protein that in humans is encoded by the SSR1 gene.[5]

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are exclusively non-canonical.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000124783 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021427 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: SSR1 signal sequence receptor, alpha (translocon-associated protein alpha)".

Further reading

  • Wei ML, Cresswell P (1992). "HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides". Nature. 356 (6368): 443–6. doi:10.1038/356443a0. PMID 1557127.
  • Vogel F, Hartmann E, Görlich D, Rapoport TA (1991). "Segregation of the signal sequence receptor protein in the rough endoplasmic reticulum membrane". Eur. J. Cell Biol. 53 (2): 197–202. PMID 1964414.
  • Hartmann E, Görlich D, Kostka S, et al. (1993). "A tetrameric complex of membrane proteins in the endoplasmic reticulum". Eur. J. Biochem. 214 (2): 375–81. doi:10.1111/j.1432-1033.1993.tb17933.x. PMID 7916687.
  • Hartmann E, Prehn S (1994). "The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges". FEBS Lett. 349 (3): 324–6. doi:10.1016/0014-5793(94)00693-8. PMID 8050590.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hu T, Guan T, Gerace L (1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hirama T, Miller CW, Koeffler HP (1999). "Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation". FEBS Lett. 455 (3): 223–7. doi:10.1016/S0014-5793(99)00885-6. PMID 10437777.
  • Wang L, Dobberstein B (1999). "Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum". FEBS Lett. 457 (3): 316–22. doi:10.1016/S0014-5793(99)01075-3. PMID 10471800.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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