SPN1

SNUPN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNUPN, KPNBL, RNUT1, Snurportin1, snurportin 1
External IDsMGI: 1913319 HomoloGene: 4166 GeneCards: SNUPN
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q24.2Start75,598,083 bp[1]
End75,626,469 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10073

66069

Ensembl

ENSG00000169371

ENSMUSG00000055334

UniProt

O95149

Q80W37

RefSeq (mRNA)

NM_005701
NM_001042581
NM_001042588

NM_178374

RefSeq (protein)

NP_001036046
NP_001036053
NP_005692

NP_848461

Location (UCSC)Chr 15: 75.6 – 75.63 MbChr 9: 56.95 – 56.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Snurportin1 is a protein that in humans is encoded by the SNUPN gene.[5][6]

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000169371 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055334 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Huber J, Cronshagen U, Kadokura M, Marshallsay C, Wada T, Sekine M, Luhrmann R (Sep 1998). "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure". EMBO J. 17 (14): 4114–26. doi:10.1093/emboj/17.14.4114. PMC 1170744. PMID 9670026.
  6. 1 2 "Entrez Gene: SNUPN snurportin 1".

Further reading

  • Paraskeva E, Izaurralde E, Bischoff FR, et al. (1999). "CRM1-mediated recycling of snurportin 1 to the cytoplasm". J. Cell Biol. 145 (2): 255–64. doi:10.1083/jcb.145.2.255. PMC 2133107. PMID 10209022.
  • Narayanan U, Ospina JK, Frey MR, et al. (2003). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta". Hum. Mol. Genet. 11 (15): 1785–95. doi:10.1093/hmg/11.15.1785. PMC 1630493. PMID 12095920.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strasser A, Dickmanns A, Lührmann R, Ficner R (2005). "Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1". EMBO J. 24 (13): 2235–43. doi:10.1038/sj.emboj.7600701. PMC 1173142. PMID 15920472.
  • Ospina JK, Gonsalvez GB, Bednenko J, et al. (2006). "Cross-talk between snurportin1 subdomains". Mol. Biol. Cell. 16 (10): 4660–71. doi:10.1091/mbc.E05-04-0316. PMC 1237072. PMID 16030253.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.


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