SOSTDC1

SOSTDC1
Identifiers
Aliases	SOSTDC1, ECTODIN, USAG1, CDA019, DAND7, sclerostin domain containing 1
External IDs	MGI: 1913292 HomoloGene: 9154 GeneCards: SOSTDC1
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	16,530,580 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	36,318,452 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• BMP binding; • BMP receptor activity;
Cellular component	• extracellular region; • extracellular space;
Biological process	• pattern specification process; • odontogenesis of dentin-containing tooth; • hair follicle morphogenesis; • mammary gland bud morphogenesis; • negative regulation of cell fate commitment; • Wnt signaling pathway; • negative regulation of canonical Wnt signaling pathway; • negative regulation of Wnt signaling pathway; • BMP signaling pathway; • negative regulation of BMP signaling pathway; • negative regulation of myoblast differentiation; • negative regulation of determination of dorsal identity;
	Sources:Amigo / QuickGO
Orthologs
	25928
	66042
	ENSG00000171243
	ENSMUSG00000036169
	Q6X4U4
	Q9CQN4
	NM_015464
	NM_025312
	NP_056279
	NP_079588
	Wikidata
View/Edit Human	View/Edit Mouse

Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.^[5]

Function

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171243 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036169 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: SOSTDC1 sclerostin domain containing 1".

Yanagita M (June 2005). "BMP antagonists: their roles in development and involvement in pathophysiology". Cytokine & Growth Factor Reviews. 16 (3): 309–17. doi:10.1016/j.cytogfr.2005.02.007. PMID 15951218.
Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N (December 2003). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Developmental Biology. 264 (1): 91–105. doi:10.1016/j.ydbio.2003.08.011. PMID 14623234.
Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T (April 2004). "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochemical and Biophysical Research Communications. 316 (2): 490–500. doi:10.1016/j.bbrc.2004.02.075. PMID 15020244.
Goto M, Eddy EM (October 2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". The Journal of Biological Chemistry. 279 (40): 42128–38. doi:10.1074/jbc.M403190200. PMID 15280373.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171243 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036169 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] 1 2 "Entrez Gene: SOSTDC1 sclerostin domain containing 1".

SOSTDC1

Function

References

Further reading