SOAT1

SOAT1
Identifiers
Aliases	SOAT1, ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT, sterol O-acyltransferase 1
External IDs	MGI: 104665 HomoloGene: 2333 GeneCards: SOAT1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.2 Start 179,293,714 bp[1] End 179,358,680 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G3|1 67.71 cM Start 156,424,525 bp[2] End 156,474,331 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • fatty-acyl-CoA binding • sterol O-acyltransferase activity • O-acyltransferase activity • cholesterol binding • protein binding • transferase activity, transferring acyl groups • cholesterol O-acyltransferase activity Cellular component • integral component of membrane • membrane • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • steroid metabolic process • macrophage derived foam cell differentiation • lipid metabolic process • cholesterol metabolic process • cholesterol esterification • cholesterol storage • cholesterol efflux • positive regulation of amyloid precursor protein biosynthetic process • very-low-density lipoprotein particle assembly • cholesterol homeostasis • low-density lipoprotein particle clearance • metabolism Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6646	20652
Ensembl	ENSG00000057252	ENSMUSG00000026600
UniProt	P35610	Q61263
RefSeq (mRNA)	NM_001252511 NM_001252512 NM_003101	NM_009230
RefSeq (protein)	NP_001239440 NP_001239441 NP_003092	NP_033256
Location (UCSC)	Chr 1: 179.29 – 179.36 Mb	Chr 1: 156.42 – 156.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1, also known as SOAT1, is an enzyme that in humans is encoded by the SOAT1 gene.^[5]

Function

Acyl-coenzyme A:cholesterol acyltransferase (EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988).^[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|px|alt=Statin Pathway edit]]

Statin Pathway edit

1. ↑ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

See also

• Acyl-CoA:cholesterol acyltransferase

References

Further reading