SLU7

SLU7
Identifiers
Aliases	SLU7, 9G8, hSlu7, SLU7 homolog, splicing factor
External IDs	MGI: 2385598 HomoloGene: 4690 GeneCards: SLU7
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	160,421,711 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	43,447,981 bp[2]
Gene ontology
Molecular function	• pre-mRNA 3'-splice site binding; • second spliceosomal transesterification activity; • metal ion binding; • protein binding; • nucleic acid binding; • zinc ion binding;
Cellular component	• cytoplasm; • nuclear speck; • catalytic step 2 spliceosome; • membrane; • intracellular membrane-bounded organelle; • small nuclear ribonucleoprotein complex; • spliceosomal complex; • cell nucleus; • nucleoplasm; • cytosol;
Biological process	• cellular response to heat; • RNA splicing, via transesterification reactions; • mRNA processing; • mRNA 3'-splice site recognition; • RNA splicing; • intracellular protein transport; • alternative mRNA splicing, via spliceosome; • RNA export from nucleus; • mRNA splicing, via spliceosome; • mRNA export from nucleus; • mRNA 3'-end processing; • termination of RNA polymerase II transcription;
	Sources:Amigo / QuickGO
Orthologs
	10569
	193116
	ENSG00000164609
	ENSMUSG00000020409
	O95391
	Q8BHJ9
	NM_006425
	NM_148673; NM_198936
	NP_006416
	NP_683514; NP_945174
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.^[5]^[6]^[7]

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164609 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020409 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Chua K, Reed R (May 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.
↑ Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.
1 2 "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".

Alberstein M, Amit M, Vaknin K, et al. (2008). "Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing". RNA. 13 (11): 1988–99. doi:10.1261/rna.492907. PMC 2040095. PMID 17804646.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Shomron N, Reznik M, Ast G (2005). "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus". Mol. Biol. Cell. 15 (8): 3782–95. doi:10.1091/mbc.E04-02-0152. PMC 491837. PMID 15181151.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chua K, Reed R (2001). "An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing". Mol. Cell. Biol. 21 (5): 1509–14. doi:10.1128/MCB.21.5.1509-1514.2001. PMC 86697. PMID 11238888.
Chua K, Reed R (2000). "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice". Nature. 402 (6758): 207–10. doi:10.1038/46086. PMID 10647016.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164609 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020409 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10197984-5] Chua K, Reed R (May 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.

[pmid15728250-6] Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.

[entrez-7] 1 2 "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".

SLU7

References

Further reading