SLA2

SLA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4M4Z
Identifiers
Aliases	SLA2, C20orf156, MARS, SLAP-2, SLAP2, Src-like-adaptor 2, Src like adaptor 2
External IDs	MGI: 1925049 HomoloGene: 49989 GeneCards: SLA2
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	36,646,216 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	156,887,192 bp[2]
Gene ontology
Molecular function	• protein binding; • protein N-terminus binding; • non-membrane spanning protein tyrosine kinase activity; • receptor binding; • SH3/SH2 adaptor activity;
Cellular component	• cytoplasm; • late endosome; • plasma membrane; • endosome membrane; • membrane; • cytoplasmic vesicle; • nucleoplasm; • Golgi apparatus; • intracellular membrane-bounded organelle; • extrinsic component of cytoplasmic side of plasma membrane;
Biological process	• negative regulation of calcium-mediated signaling; • negative regulation of B cell activation; • intracellular receptor signaling pathway; • negative regulation of transcription from RNA polymerase II promoter; • T cell activation; • B cell mediated immunity; • regulation of immune response; • antigen receptor-mediated signaling pathway; • positive regulation of signal transduction; • transmembrane receptor protein tyrosine kinase signaling pathway; • cell migration; • cell differentiation; • peptidyl-tyrosine autophosphorylation; • regulation of cell proliferation; • innate immune response; • regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	84174
	77799
	ENSG00000101082
	ENSMUSG00000027636
	Q9H6Q3
	Q8R4L0
	NM_032214; NM_175077
	NM_029983; NM_001356495
	NP_115590; NP_778252
	NP_084259; NP_001343424
	Wikidata
View/Edit Human	View/Edit Mouse

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.^[5]^[6]

Function

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.^[6]

Interactions

SLA2 has been shown to interact with Cbl gene.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101082 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027636 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med. 194 (9): 1263–76. doi:10.1084/jem.194.9.1263. PMC 2195979. PMID 11696592.
1 2 "Entrez Gene: SLA2 Src-like-adaptor 2".
↑ Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.

Loreto MP, McGlade CJ (2003). "Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v". Oncogene. 22 (2): 266–73. doi:10.1038/sj.onc.1206114. PMID 12527895.
Loreto MP, Berry DM, McGlade CJ (2002). "Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling". Mol. Cell. Biol. 22 (12): 4241–55. doi:10.1128/MCB.22.12.4241-4255.2002. PMC 133880. PMID 12024036.
Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101082 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027636 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid11696592-5] Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med. 194 (9): 1263–76. doi:10.1084/jem.194.9.1263. PMC 2195979. PMID 11696592.

[entrez-6] 1 2 "Entrez Gene: SLA2 Src-like-adaptor 2".

[pmid11891219-7] Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.

SLA2

Function

Interactions

References

Further reading