SKIV2L

SKIV2L
Identifiers
AliasesSKIV2L, 170A, DDX13, HLP, SKI2, SKI2W, SKIV2, THES2, SKIV2L1, Ski2 like RNA helicase
External IDsMGI: 1099835 HomoloGene: 123971 GeneCards: SKIV2L
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.33Start31,959,080 bp[1]
End31,969,755 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6499

108077

Ensembl

ENSMUSG00000040356

UniProt

Q15477

n/a

RefSeq (mRNA)

NM_006929

NM_021337
NM_178062

RefSeq (protein)

NP_008860

n/a

Location (UCSC)Chr 6: 31.96 – 31.97 MbChr 17: 34.84 – 34.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Helicase SKI2W is an enzyme that in humans is encoded by the SKIV2L gene.[5][6][7]

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex.[7]

References

  1. 1 2 3 ENSG00000204351, ENSG00000228896, ENSG00000206353, ENSG00000223493, ENSG00000225737 GRCh38: Ensembl release 89: ENSG00000232616, ENSG00000204351, ENSG00000228896, ENSG00000206353, ENSG00000223493, ENSG00000225737 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040356 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Lee SG, Lee I, Park SH, Kang C, Song K (February 1995). "Identification and characterization of a human cDNA homologous to yeast SKI2". Genomics. 25 (3): 660–6. doi:10.1016/0888-7543(95)80008-A. PMID 7759100.
  6. ↑ Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (November 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
  7. 1 2 "Entrez Gene: SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)".

Further reading

  • Yang Z, Qu X, Yu CY (August 2001). "Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region". Frontiers in Bioscience. 6: D927–35. doi:10.2741/Yang. PMID 11487501.
  • Dangel AW, Shen L, Mendoza AR, Wu LC, Yu CY (June 1995). "Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family". Nucleic Acids Research. 23 (12): 2120–6. doi:10.1093/nar/23.12.2120. PMC 306998. PMID 7610041.
  • Shen L, Wu LC, Sanlioglu S, Chen R, Mendoza AR, Dangel AW, Carroll MC, Zipf WB, Yu CY (March 1994). "Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication". The Journal of Biological Chemistry. 269 (11): 8466–76. PMID 8132574.
  • Albertella MR, Jones H, Thomson W, Olavesen MG, Campbell RD (September 1996). "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B)". Genomics. 36 (2): 240–51. doi:10.1006/geno.1996.0459. PMID 8812450.
  • Lee SG, Song K (June 1997). "Genomic organization of the human DDX13 gene located between RD and RP1 in the class III MHC complex". Molecules and Cells. 7 (3): 414–8. PMID 9264031.
  • Qu X, Yang Z, Zhang S, Shen L, Dangel AW, Hughes JH, Redman KL, Wu LC, Yu CY (September 1998). "The human DEVH-box protein Ski2w from the HLA is localized in nucleoli and ribosomes". Nucleic Acids Research. 26 (17): 4068–77. doi:10.1093/nar/26.17.4068. PMC 147813. PMID 9705521.
  • Lee SG, Song K (February 2000). "Identification and characterization of a bidirectional promoter from the intergenic region between the human DDX13 and RD genes". Molecules and Cells. 10 (1): 47–53. doi:10.1007/s10059-000-0047-z. PMID 10774746.
  • Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (November 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
  • Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Yang CT, Hindes AE, Hultman KA, Johnson SL (June 2007). "Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish". PLoS Genetics. 3 (6): e88. doi:10.1371/journal.pgen.0030088. PMC 1885281. PMID 17542649.


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