SIGIRR

SIGIRR
Identifiers
AliasesSIGIRR, TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, IL-1R8, single Ig and TIR domain containing
External IDsMGI: 1344402 HomoloGene: 36399 GeneCards: SIGIRR
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.5Start405,716 bp[1]
End417,455 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

59307

24058

Ensembl

ENSG00000185187

ENSMUSG00000025494

UniProt

Q6IA17

Q9JLZ8

RefSeq (mRNA)

NM_001135053
NM_001135054
NM_021805

NM_023059
NM_001355055

RefSeq (protein)

NP_001128525
NP_001128526
NP_068577

NP_075546
NP_001341984

Location (UCSC)Chr 11: 0.41 – 0.42 MbChr 7: 141.09 – 141.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene.[5][6]

It has been observed to modulate immune responses, colonic epithelial homeostasis and tumorigenesis.[7][8]

Interactions

SIGIRR has been shown to interact with TRAF6.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000185187 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025494 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Thomassen E, Renshaw BR, Sims JE (Jul 1999). "Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily". Cytokine. 11 (6): 389–99. doi:10.1006/cyto.1998.0452. PMID 10346978.
  6. ↑ "Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain".
  7. 1 2 Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X (September 2003). "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling". Nat. Immunol. 4 (9): 920–7. doi:10.1038/ni968. PMID 12925853.
  8. ↑ Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D, Vallance BA, Li X (April 2007). "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis". Immunity. 26 (4): 461–75. doi:10.1016/j.immuni.2007.02.012. PMID 17398123.

Further reading

  • Du X, Poltorak A, Wei Y, Beutler B (2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Polentarutti N, Rol GP, Muzio M, et al. (2004). "Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR". Eur. Cytokine Netw. 14 (4): 211–8. PMID 14715412.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Qin J, Qian Y, Yao J, et al. (2005). "SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms". J. Biol. Chem. 280 (26): 25233–41. doi:10.1074/jbc.M501363200. PMID 15866876.


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