SHPRH

SHPRH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSHPRH, bA545I5.2, SNF2 histone linker PHD RING helicase
External IDsMGI: 1917581 HomoloGene: 6489 GeneCards: SHPRH
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q24.3Start145,864,245 bp[1]
End145,964,423 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

257218

268281

Ensembl

ENSG00000146414

ENSMUSG00000090112

UniProt

Q149N8

Q7TPQ3

RefSeq (mRNA)

NM_001042683
NM_173082

NM_001077707
NM_001284354
NM_172937

RefSeq (protein)

NP_001036148
NP_775105

NP_001071175
NP_001271283
NP_766525

Location (UCSC)Chr 6: 145.86 – 145.96 MbChr 10: 11.15 – 11.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.[5][6]

Function

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000146414 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090112 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (August 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region". Genomics. 82 (2): 153–61. doi:10.1016/S0888-7543(03)00121-6. PMID 12837266.
  6. 1 2 "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase".

Further reading

  • Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K (December 2006). "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination". The Journal of Cell Biology. 175 (5): 703–8. doi:10.1083/jcb.200606145. PMC 2064669. PMID 17130289.
  • Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L (November 2006). "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18107–12. doi:10.1073/pnas.0608595103. PMC 1838714. PMID 17108083.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
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