SH3RF1

SH3RF1
Identifiers
Aliases	SH3RF1, POSH, RNF142, SH3MD2, SH3 domain containing ring finger 1
External IDs	MGI: 1913066 HomoloGene: 10988 GeneCards: SH3RF1
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	169,271,105 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	61,396,071 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein binding; • metal ion binding; • transferase activity; • MAP-kinase scaffold activity; • ubiquitin protein ligase activity;
Cellular component	• cytoplasm; • perinuclear region of cytoplasm; • cytosol; • Golgi apparatus; • cell projection; • lamellipodium;
Biological process	• negative regulation of extrinsic apoptotic signaling pathway; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • negative regulation of apoptotic process; • regulation of JNK cascade; • protein ubiquitination; • apoptotic process; • neuron migration; • activation of JUN kinase activity; • regulation of CD4-positive, alpha-beta T cell differentiation; • protein autoubiquitination; • regulation of CD8-positive, alpha-beta T cell proliferation; • positive regulation of JNK cascade;
	Sources:Amigo / QuickGO
Orthologs
	57630
	59009
	ENSG00000154447
	ENSMUSG00000031642
	Q7Z6J0
	Q69ZI1
	NM_020870
	NM_021506; NM_198678
	NP_065921
	NP_067481
	Wikidata
View/Edit Human	View/Edit Mouse

Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene.^[5]^[6]

Function

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.^[6]

Interactions

SH3RF1 has been shown to interact with AKT2^[7] and MAP3K11.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000154447 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031642 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Tapon N, Nagata K, Lamarche N, Hall A (Apr 1998). "A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways". EMBO J. 17 (5): 1395–404. doi:10.1093/emboj/17.5.1395. PMC 1170487. PMID 9482736.
1 2 "Entrez Gene: SH3RF1 SH3 domain containing ring finger 1".
1 2 Figueroa C, Tarras S, Taylor J, Vojtek AB (Nov 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.

Lyons TR, Thorburn J, Ryan PW, Thorburn A, Anderson SM, Kassenbrock CK (2007). "Regulation of the Pro-apoptotic scaffolding protein POSH by Akt". J. Biol. Chem. 282 (30): 21987–97. doi:10.1074/jbc.M704321200. PMID 17535800.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Alroy I, Tuvia S, Greener T, Gordon D, Barr HM, Taglicht D, Mandil-Levin R, Ben-Avraham D, Konforty D, Nir A, Levius O, Bicoviski V, Dori M, Cohen S, Yaar L, Erez O, Propheta-Meiran O, Koskas M, Caspi-Bachar E, Alchanati I, Sela-Brown A, Moskowitz H, Tessmer U, Schubert U, Reiss Y (2005). "The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1478–83. doi:10.1073/pnas.0408717102. PMC 545085. PMID 15659549.
Figueroa C, Tarras S, Taylor J, Vojtek AB (2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.
Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000154447 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031642 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9482736-5] Tapon N, Nagata K, Lamarche N, Hall A (Apr 1998). "A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways". EMBO J. 17 (5): 1395–404. doi:10.1093/emboj/17.5.1395. PMC 1170487. PMID 9482736.

[entrez-6] 1 2 "Entrez Gene: SH3RF1 SH3 domain containing ring finger 1".

[pmid14504284-7] 1 2 Figueroa C, Tarras S, Taylor J, Vojtek AB (Nov 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.

SH3RF1

Function

Interactions

References

Further reading