SH2D2A

SH2D2A
Identifiers
AliasesSH2D2A, F2771, SCAP, TSAD, VRAP, SH2 domain containing 2A
External IDsMGI: 1351596 HomoloGene: 2958 GeneCards: SH2D2A
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.1Start156,806,243 bp[1]
End156,816,862 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9047

27371

Ensembl

ENSG00000027869

ENSMUSG00000028071

UniProt

Q9NP31

Q9QXK9

RefSeq (mRNA)

NM_001161441
NM_001161442
NM_001161443
NM_001161444
NM_003975

NM_001025571
NM_021309

RefSeq (protein)

NP_001154913
NP_001154914
NP_001154915
NP_001154916
NP_003966

NP_001020742
NP_067284

Location (UCSC)Chr 1: 156.81 – 156.82 MbChr 3: 87.85 – 87.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SH2 domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene.[5][6]

Interactions

SH2D2A has been shown to interact with MAP3K2.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000027869 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028071 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Spurkland A; Brinchmann JE; Markussen G; Pedeutour F; Munthe E; Lea T; Vartdal F; Aasheim HC (March 1998). "Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites". J Biol Chem. 273 (8): 4539–46. doi:10.1074/jbc.273.8.4539. PMID 9468509.
  6. ↑ "Entrez Gene: SH2D2A SH2 domain protein 2A".
  7. ↑ Sun, W; Kesavan K; Schaefer B C; Garrington T P; Ware M; Johnson N L; Gelfand E W; Johnson G L (February 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". J. Biol. Chem. United States. 276 (7): 5093–100. doi:10.1074/jbc.M003719200. ISSN 0021-9258. PMID 11073940.

Further reading

  • Marti F; Lapinski PE; King PD (2005). "The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man". Immunol. Lett. 97 (2): 165–70. doi:10.1016/j.imlet.2004.10.019. PMID 15752554.
  • Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Choi YB; Kim CK; Yun Y (1999). "Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation". J. Immunol. 163 (10): 5242–9. PMID 10553045.
  • Rajagopal K, Sommers CL, Decker DC, et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation". J. Exp. Med. 190 (11): 1657–68. doi:10.1084/jem.190.11.1657. PMC 2195727. PMID 10587356.
  • Wu LW, Mayo LD, Dunbar JD, et al. (2000). "VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor". J. Biol. Chem. 275 (9): 6059–62. doi:10.1074/jbc.275.9.6059. PMID 10692392.
  • Dai KZ, Vergnaud G, Ando A, et al. (2000). "The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1". Immunogenetics. 51 (3): 179–85. doi:10.1007/s002510050029. PMID 10752626.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Smerdel A, Dai KZ, Lorentzen AR, et al. (2005). "Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene". Genes Immun. 5 (4): 310–2. doi:10.1038/sj.gene.6364093. PMID 15129233.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
  • Matsumoto T, Bohman S, Dixelius J, et al. (2005). "VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis". EMBO J. 24 (13): 2342–53. doi:10.1038/sj.emboj.7600709. PMC 1173150. PMID 15962004.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Park D, Park I, Lee D, et al. (2007). "The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration". Blood. 109 (12): 5122–8. doi:10.1182/blood-2005-10-061838. PMID 17327418.


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