SGSM2

SGSM2
Identifiers
AliasesSGSM2, RUTBC1, small G protein signaling modulator 2
External IDsMGI: 2144695 HomoloGene: 14780 GeneCards: SGSM2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.3Start2,337,498 bp[1]
End2,381,058 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9905

97761

Ensembl

ENSG00000141258

ENSMUSG00000038351

UniProt

O43147

Q80U12

RefSeq (mRNA)

NM_001098509
NM_014853
NM_001346700

NM_197943

RefSeq (protein)

NP_001091979
NP_001333629
NP_055668

NP_922934

Location (UCSC)Chr 17: 2.34 – 2.38 MbChr 11: 74.85 – 74.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.[5][6]

Clinical relevance

In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000141258 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038351 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Yang, H; et al. (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–260. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
  6. ↑ "Entrez Gene: small G protein signaling modulator 2".
  7. ↑ Strawbridge, RJ; et al. (2011-08-26). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes". Diabetes. 60 (10): 2624–34. doi:10.2337/db11-0415. PMC 3178302. PMID 21873549.

Further reading

  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Vasan RS, Glazer NL, Felix JF, et al. (2009). "Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data". JAMA. 302 (2): 168–78. doi:10.1001/jama.2009.978-a. PMC 2975567. PMID 19584346.
  • Ishikawa K, Nagase T, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  • Yang H; Sasaki T; Minoshima S; Shimizu N (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–60. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
  • Ishibashi K; Kanno E; Itoh T; Fukuda M (2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity". Genes Cells. 14 (1): 41–52. doi:10.1111/j.1365-2443.2008.01251.x. PMID 19077034.


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