SEPT10

SEPT10
Identifiers
Aliases	SEPT10, septin 10
External IDs	MGI: 1918110 HomoloGene: 27035 GeneCards: SEPT10
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	109,614,206 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	59,221,847 bp[2]
Gene ontology
Molecular function	• nucleotide binding; • GTP binding; • protein binding; • GTPase activity; • protein complex scaffold activity;
Cellular component	• cytoplasm; • cytoskeleton; • septin ring; • microtubule cytoskeleton; • septin complex; • septin filament array;
Biological process	• cell cycle; • cell division; • mitotic cytokinesis; • septin ring assembly; • cilium morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	151011
	103080
	ENSG00000186522
	ENSMUSG00000019917
	Q9P0V9
	Q8C650
NM_144710; NM_178584; NM_001321496; NM_001321498; NM_001321499;
	NM_001321500; NM_001321501; NM_001321502; NM_001321503; NM_001321504; NM_001321505; NM_001321506; NM_001321507; NM_001321508; NM_001321509; NM_001321510; NM_001321511; NM_001321512; NM_001321513; NM_001321514; NM_001321515
	NM_001024910; NM_001024911
NP_001308425; NP_001308427; NP_001308428; NP_001308429; NP_001308430;
	NP_001308431; NP_001308432; NP_001308433; NP_001308434; NP_001308435; NP_001308436; NP_001308437; NP_001308438; NP_001308439; NP_001308440; NP_001308441; NP_001308442; NP_001308443; NP_001308444; NP_653311; NP_848699; NP_001308427.1
	NP_001020081; NP_001020082
	Wikidata
View/Edit Human	View/Edit Mouse

Septin 10 is a protein that in humans is encoded by the SEPT10 gene.^[5]

Function

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternative splicing results in multiple transcript variants.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186522 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019917 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: Septin 10".

Sui L, Zhang W, Liu Q, Chen T, Li N, Wan T, Yu M, Cao X (May 2003). "Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells". Biochemical and Biophysical Research Communications. 304 (2): 393–8. doi:10.1016/s0006-291x(03)00601-6. PMID 12711328.
Benedetti D, Bomben R, Dal-Bo M, Marconi D, Zucchetto A, Degan M, Forconi F, Del-Poeta G, Gaidano G, Gattei V (January 2008). "Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10". Leukemia. 22 (1): 224–6. doi:10.1038/sj.leu.2404867. PMID 17657217.
Xu M, Takanashi M, Oikawa K, Nishi H, Isaka K, Yoshimoto T, Ohyashiki J, Kuroda M (April 2012). "Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen". Cancer Science. 103 (4): 821–7. doi:10.1111/j.1349-7006.2012.02221.x. PMID 22320903.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186522 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019917 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] 1 2 "Entrez Gene: Septin 10".

SEPT10

Function

References

Further reading