SENP8

SENP8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSENP8, DEN1, NEDP1, PRSC2, SUMO/sentrin peptidase family member, NEDD8 specific, SUMO peptidase family member, NEDD8 specific
External IDsMGI: 1918849 HomoloGene: 14084 GeneCards: SENP8
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q23Start72,114,258 bp[1]
End72,143,688 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

123228

71599

Ensembl

ENSG00000166192

ENSMUSG00000051705

UniProt

Q96LD8

Q9D2Z4

RefSeq (mRNA)

NM_001166340
NM_001172109
NM_001172110
NM_001172111
NM_145204

NM_001172068
NM_001172069
NM_001172070
NM_001172071
NM_027838

RefSeq (protein)

NP_001159812
NP_001165580
NP_001165581
NP_001165582
NP_660205

NP_001165539
NP_001165540
NP_001165541
NP_001165542
NP_082114

Location (UCSC)Chr 15: 72.11 – 72.14 MbChr 9: 59.73 – 59.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.[5][6][7]

NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003).[supplied by OMIM][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166192 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051705 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, Ink B, Hay RT (Jul 2003). "NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins". J Biol Chem. 278 (28): 25637–43. doi:10.1074/jbc.M212948200. PMID 12730221.
  6. ↑ Gan-Erdene T, Nagamalleswari K, Yin L, Wu K, Pan ZQ, Wilkinson KD (Jul 2003). "Identification and characterization of DEN1, a deneddylase of the ULP family". J Biol Chem. 278 (31): 28892–900. doi:10.1074/jbc.M302890200. PMID 12759362.
  7. 1 2 "Entrez Gene: SENP8 SUMO/sentrin specific peptidase family member 8".

Further reading

  • Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS (2007). "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs". J. Biol. Chem. 282 (36): 26217–24. doi:10.1074/jbc.M702444200. PMID 17591783.
  • Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS (2008). "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family". Biochem. J. 409 (2): 461–9. doi:10.1042/BJ20070940. PMID 17916063.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wu K, Yamoah K, Dolios G, et al. (2003). "DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1". J. Biol. Chem. 278 (31): 28882–91. doi:10.1074/jbc.M302888200. PMID 12759363.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Xirodimas DP, Saville MK, Bourdon JC, et al. (2004). "Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity". Cell. 118 (1): 83–97. doi:10.1016/j.cell.2004.06.016. PMID 15242646.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Reverter D, Wu K, Erdene TG, et al. (2005). "Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1". J. Mol. Biol. 345 (1): 141–51. doi:10.1016/j.jmb.2004.10.022. PMID 15567417.
  • Shen LN, Liu H, Dong C, et al. (2005). "Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1". EMBO J. 24 (7): 1341–51. doi:10.1038/sj.emboj.7600628. PMC 1142549. PMID 15775960.


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