SEMA4A

SEMA4A
Identifiers
AliasesSEMA4A, CORD10, RP35, SEMAB, SEMB, semaphorin 4A
External IDsMGI: 107560 HomoloGene: 8425 GeneCards: SEMA4A
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q22Start156,147,366 bp[1]
End156,177,752 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64218

20351

Ensembl

ENSG00000196189

ENSMUSG00000028064

UniProt

Q9H3S1

Q62178

RefSeq (mRNA)

NM_001193300
NM_001193301
NM_001193302
NM_022367

NM_001163489
NM_001163490
NM_001163491
NM_013658

RefSeq (protein)

NP_001180229
NP_001180230
NP_001180231
NP_071762

NP_001156961
NP_001156962
NP_001156963
NP_038686

Location (UCSC)Chr 1: 156.15 – 156.18 MbChr 3: 88.44 – 88.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.[5][6]

Function

SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM][6]

Clinical significance

A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196189 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028064 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Püschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
  6. 1 2 "Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A".
  7. ↑ Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, Kashofer K, Nojima S, Leitner A, Zebisch A, Wölfler A, Hofer S, Gerger A, Lax S, Beham-Schmid C, Steinke V, Heitzer E, Geigl JB, Windpassinger C, Hoefler G, Speicher MR, Richard Boland C, Kumanogoh A, Sill H (Oct 2014). "Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X." Nature Communications. 5: 5191. doi:10.1038/ncomms6191. PMC 4214414. PMID 25307848.

Further reading

  • Kikutani H, Kumanogoh A (2003). "Semaphorins in interactions between T cells and antigen-presenting cells". Nat. Rev. Immunol. 3 (2): 159–67. doi:10.1038/nri1003. PMID 12563299.
  • Kumanogoh A, Kikutani H (2004). "Immune semaphorins: a new area of semaphorin research". J. Cell Sci. 116 (Pt 17): 3463–70. doi:10.1242/jcs.00674. PMID 12893810.
  • Elhabazi A, Marie-Cardine A, Chabbert-de Ponnat I, Bensussan A, Boumsell L (2004). "Structure and function of the immune semaphorin CD100/SEMA4D". Crit. Rev. Immunol. 23 (1–2): 65–81. doi:10.1615/CritRevImmunol.v23.i12.40. PMID 12906260.
  • Kumanogoh A, Marukawa S, Suzuki K, Takegahara N, Watanabe C, Ch'ng E, Ishida I, Fujimura H, Sakoda S, Yoshida K, Kikutani H (2002). "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2". Nature. 419 (6907): 629–33. doi:10.1038/nature01037. PMID 12374982.
  • Abid A, Ismail M, Mehdi SQ, Khaliq S (2006). "Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases". J. Med. Genet. 43 (4): 378–81. doi:10.1136/jmg.2005.035055. PMC 2563224. PMID 16199541.
  • Nkyimbeng-Takwi E, Chapoval SP (2011). "Biology and function of neuroimmune semaphorins 4A and 4D". Immunol. Res. 50 (1): 10–21. doi:10.1007/s12026-010-8201-y. PMC 3366695. PMID 21203905.
  • Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (2011). "Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor". BMC Immunol. 12: 30. doi:10.1186/1471-2172-12-30. PMC 3118960. PMID 21595947.
  • Nkyimbeng-Takwi EH, Shanks K, Smith E, Iyer A, Lipsky MM, Detolla LJ, Kikutani H, Keegan AD, Chapoval SP (2012). "Neuroimmune semaphorin 4A downregulates the severity of allergic response". Mucosal Immunol. 5 (4): 409–19. doi:10.1038/mi.2012.18. PMC 3378810. PMID 22472774.
  • Mogie G, Shanks K, Nkyimbeng-Takwi EH, Smith E, Davila E, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (2013). "Neuroimmune semaphorin 4A as a drug and drug target for asthma". Int. Immunopharmacol. 17 (3): 568–75. doi:10.1016/j.intimp.2013.08.005. PMC 3818409. PMID 23994348.
  • Chapoval SP (2015). "Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis". Arthritis Res. Ther. 17: 313. doi:10.1186/s13075-015-0846-4. PMC 4635990. PMID 26542940.


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