SELT

SELENOT
Identifiers
AliasesSELENOT, SELT, selenoprotein T
External IDsMGI: 1916477 HomoloGene: 32304 GeneCards: SELENOT
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q25.1Start150,602,875 bp[1]
End150,630,445 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51714

69227

Ensembl

ENSG00000198843

ENSMUSG00000075700

UniProt

P62341

P62342

RefSeq (mRNA)

NM_016275

NM_001040396

RefSeq (protein)

NP_057359

NP_001035486

Location (UCSC)Chr 3: 150.6 – 150.63 MbChr 3: 58.58 – 58.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene.[5][6][7]

Gene

The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.[7]

Protein structure

Selenoprotein T contains a selenocysteine (Sec) residue at its active site.

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198843 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075700 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Kryukov GV, Kryukov VM, Gladyshev VN (November 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.
  6. ↑ Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. doi:10.1126/science.1083516. PMID 12775843.
  7. 1 2 "Entrez Gene: SELT selenoprotein T".

Further reading

  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.


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