SEDLP

TRAPPC2B
Identifiers
AliasesTRAPPC2B, MIP-2A, SEDLP, SEDLP1, TRAPPC2P1, trafficking protein particle complex 2B
External IDsGeneCards: TRAPPC2B
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.43Start57,363,511 bp[1]
End57,365,353 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10597

n/a

Ensembl

ENSG00000256060

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

NM_001355204

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 19: 57.36 – 57.37 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Trafficking protein particle complex subunit 2 is a protein that in humans is encoded by the TRAPPC2P1 gene.[3]

This gene has been described as a transcribed retropseudogene (or retro-xaptonuon) based on its structure which lacks most of the introns of SEDL and the detection of transcripts from this locus. Most retropseudogenes are thought to not express protein products. A protein product could potentially be encoded by this retropseudogene that would be identical to the protein product of the SEDL gene. However, it remains unclear whether this gene encodes a protein product or is a transcribed retropseudogene.[3]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000256060 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. 1 2 "Entrez Gene: SEDLP spondyloepiphyseal dysplasia, late, pseudogene".

Further reading

  • Sacher M (2003). "Membrane traffic fuses with cartilage development". FEBS Lett. 550 (1–3): 1–4. doi:10.1016/S0014-5793(03)00854-8. PMID 12935876.
  • Gécz J, Hillman MA, Gedeon AK, et al. (2001). "Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda". Genomics. 69 (2): 242–51. doi:10.1006/geno.2000.6326. PMID 11031107.
  • Ghosh AK, Majumder M, Steele R, et al. (2001). "A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1". Mol. Cell. Biol. 21 (2): 655–62. doi:10.1128/MCB.21.2.655-662.2001. PMC 86643. PMID 11134351.
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ghosh AK, Steele R, Ray RB (2003). "Modulation of human luteinizing hormone beta gene transcription by MIP-2A". J. Biol. Chem. 278 (26): 24033–8. doi:10.1074/jbc.M211982200. PMID 12700240.
  • Savarirayan R, Thompson E, Gécz J (2004). "Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400)". Eur. J. Hum. Genet. 11 (9): 639–42. doi:10.1038/sj.ejhg.5201025. PMID 12939648.
  • Gécz J, Shaw MA, Bellon JR, de Barros Lopes M (2004). "Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not". Gene. 320: 137–44. doi:10.1016/S0378-1119(03)00819-9. PMID 14597397.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.


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