SDK2

SDK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSDK2, sidekick cell adhesion molecule 2
External IDsMGI: 2443847 HomoloGene: 10406 GeneCards: SDK2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.1Start73,334,384 bp[1]
End73,644,089 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54549

237979

Ensembl

ENSG00000069188

ENSMUSG00000041592

UniProt

Q58EX2

Q6V4S5

RefSeq (mRNA)

NM_001144952
NM_019064

NM_172800

RefSeq (protein)

NP_001138424

NP_766388

Location (UCSC)Chr 17: 73.33 – 73.64 MbChr 11: 113.78 – 114.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
For the Japanese game, see Super Donkey Kong 2

Protein sidekick-2 is a protein that in humans is encoded by the SDK2 gene.[5][6][7]

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000069188 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041592 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Yamagata M, Weiner JA, Sanes JR (Sep 2002). "Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina". Cell. 110 (5): 649–60. doi:10.1016/S0092-8674(02)00910-8. PMID 12230981.
  6. ↑ Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE (Jun 2004). "Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy". J Am Soc Nephrol. 15 (7): 1721–30. doi:10.1097/01.ASN.0000128975.28958.C2. PMID 15213259.
  7. 1 2 "Entrez Gene: SDK2 sidekick homolog 2 (chicken)".

Further reading

  • Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  • Nguyen DN, Liu Y, Litsky ML, Reinke R (1997). "The sidekick gene, a member of the immunoglobulin superfamily, is required for pattern formation in the Drosophila eye". Development. 124 (17): 3303–12. PMID 9310325.


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