SCUBE1

SCUBE1
Identifiers
AliasesSCUBE1, signal peptide, CUB domain and EGF like domain containing 1
External IDsMGI: 1890616 HomoloGene: 11224 GeneCards: SCUBE1
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.2Start43,197,283 bp[1]
End43,343,388 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

80274

64706

Ensembl

ENSG00000159307

ENSMUSG00000016763

UniProt

Q8IWY4

Q6NZL8

RefSeq (mRNA)

NM_173050

NM_001271472
NM_001271473
NM_022723

RefSeq (protein)

NP_766638
NP_766638.2

NP_001258401
NP_001258402
NP_073560

Location (UCSC)Chr 22: 43.2 – 43.34 MbChr 15: 83.6 – 83.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal peptide, CUB domain and EGF like domain containing 1 is a protein that in humans is encoded by the SCUBE1 gene. [5]

Function

This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000159307 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016763 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Signal peptide, CUB domain and EGF like domain containing 1". Retrieved 2017-05-31.

Further reading

  • Yang RB, Ng CK, Wasserman SM, Colman SD, Shenoy S, Mehraban F, Komuves LG, Tomlinson JE, Topper JN (2002). "Identification of a novel family of cell-surface proteins expressed in human vascular endothelium". J. Biol. Chem. 277 (48): 46364–73. doi:10.1074/jbc.M207410200. PMID 12270931.
  • Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, Fortin PR, Wither J, Rioux JD (2011). "A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles". Genes Immun. 12 (1): 51–8. doi:10.1038/gene.2010.47. PMID 20962850.
  • Ulusoy S, Ozkan G, Menteşe A, Yavuz A, Karahan SC, Sümer AU (2012). "Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level". Clin. Biochem. 45 (16–17): 1444–9. doi:10.1016/j.clinbiochem.2012.07.103. PMID 22874483.
  • Orr B, Grace OC, Brown P, Riddick AC, Stewart GD, Franco OE, Hayward SW, Thomson AA (2013). "Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1". Dis Model Mech. 6 (2): 530–6. doi:10.1242/dmm.010355. PMC 3597035. PMID 23136397.
  • Mentese A, Fidan E, Sumer AU, Karahan SC, Sonmez M, Altay DU, Kavgaci H, Alver A (2012). "Is SCUBE 1 a new biomarker for gastric cancer?". Cancer Biomark. 11 (5): 191–5. doi:10.3233/CBM-2012-00285. PMID 23220851.
  • Menteşe A, Yilmaz G, Sümer A, Arslan M, Karahan SC, Köksal I (2013). "The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever". Int. J. Infect. Dis. 17 (11): e1042–5. doi:10.1016/j.ijid.2013.03.014. PMID 23632301.
  • Topcu TO, Kavgaci H, Ozdemir F, Aksoy A, Erdem D, Mentese A, Yaman H, Tufan G, Orem A, Aydin F (2015). "Elevated Serum Levels of SCUBE1, a Marker for Coagulation, in Patients with Breast Cancer". Tohoku J. Exp. Med. 237 (2): 127–32. doi:10.1620/tjem.237.127. PMID 26438214.
  • Liao WJ, Tsao KC, Yang RB (2016). "Electrostatics and N-glycan-mediated membrane tethering of SCUBE1 is critical for promoting bone morphogenetic protein signalling". Biochem. J. 473 (5): 661–72. doi:10.1042/BJ20151041. PMID 26699903.
  • Chen QH, Lin D, Zhou J, Deng G (2016). "Role of signal peptide-Cub-Egf domain-containing protein-1 in serum as a predictive biomarker of outcome after severe traumatic brain injury". Clin. Chim. Acta. 456: 63–6. doi:10.1016/j.cca.2016.02.021. PMID 26940951.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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