SCAMP3

SCAMP3
Identifiers
AliasesSCAMP3, C1orf3, secretory carrier membrane protein 3
External IDsMGI: 1346346 HomoloGene: 4164 GeneCards: SCAMP3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q22Start155,255,979 bp[1]
End155,262,430 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10067

24045

Ensembl

ENSG00000263290
ENSG00000116521

ENSMUSG00000028049

UniProt

O14828

O35609

RefSeq (mRNA)

NM_005698
NM_052837

NM_011886
NM_001309909
NM_001309910

RefSeq (protein)

NP_005689
NP_443069

NP_001296838
NP_001296839
NP_036016

Location (UCSC)Chr 1: 155.26 – 155.26 MbChr 3: 89.18 – 89.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Secretory carrier-associated membrane protein 3 is a protein that in humans is encoded by the SCAMP3 gene.[5][6][7]

Function

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Two transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

SCAMP3 has been shown to interact with NEDD4.[8]

References

  1. 1 2 3 ENSG00000116521 GRCh38: Ensembl release 89: ENSG00000263290, ENSG00000116521 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028049 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E (October 1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Research. 7 (10): 1020–6. doi:10.1101/gr.7.10.1020. PMC 310674. PMID 9331372.
  6. ↑ Wu TT, Castle JD (July 1998). "Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor". Molecular Biology of the Cell. 9 (7): 1661–74. doi:10.1091/mbc.9.7.1661. PMC 25404. PMID 9658162.
  7. 1 2 "Entrez Gene: SCAMP3 secretory carrier membrane protein 3".
  8. ↑ Aoh QL, Castle AM, Hubbard CH, Katsumata O, Castle JD (March 2009). "SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling". Molecular Biology of the Cell. 20 (6): 1816–32. doi:10.1091/mbc.E08-09-0894. PMC 2655259. PMID 19158374.

Further reading

  • Wu TT, Castle JD (July 1997). "Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs)". Journal of Cell Science. 110 ( Pt 13) (13): 1533–41. PMID 9224770.
  • Singleton DR, Wu TT, Castle JD (September 1997). "Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions". Journal of Cell Science. 110 ( Pt 17) (17): 2099–107. PMID 9378760.
  • Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (April 2000). "SCAMP1 function in endocytosis". The Journal of Biological Chemistry. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.
  • Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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